生长分化因子/骨形态发生蛋白（GDF/BMP）家族成员信号肽的广泛序列更替：探索其进化图景。

Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape.

作者信息

Veitia Reiner A, Caburet Sandrine

机构信息

Institut Jacques Monod, UMR 8104, CNRS, Paris, France.

出版信息

Biol Direct. 2009 Jul 16;4:22. doi: 10.1186/1745-6150-4-22.

DOI:10.1186/1745-6150-4-22

PMID:19607682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2717928/

Abstract

UNLABELLED

We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.

REVIEWERS

This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin.

摘要

未标注

我们发现，分泌因子GDF9、BMP15和AMH的预测信号肽（SP）序列在哺乳动物中高度保守，但在更远缘的直系同源物中则出现了显著差异。有趣的是，生物信息学预测表明，这些 divergent 蛋白片段确实编码信号肽。因此，此类信号肽经历了广泛的序列更替，但其功能却完全得以保留。这可以通过中性和补偿性突变的普遍积累来解释。本文还探讨了一些信号肽潜在的进化格局。其中一些信号序列凸显了一个明显的悖论：根据定义，它们由直系同源DNA片段编码，但鉴于其显著的差异，它们又是功能趋同的实例。