Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara-City, Kanagawa 259-1193, Japan.
Pathol Res Pract. 2010 Feb 15;206(2):98-101. doi: 10.1016/j.prp.2009.06.010. Epub 2009 Jul 15.
Fatty acid binding protein-7 (FABP-7) is normally expressed in the mammary gland. The aim of this study was to clarify the phenotype of breast cancers with respect to the overexpression of FABP-7. Reverse transcription PCR (RT-PCR) analysis was carried out on 16 cases, including 4 ER(+)/HER2(-), 2 ER(+)/HER2(+), 3 ER(-)/HER2(+), and 5 ER(-)/HER2(-) samples, and 2 non-neoplastic mammary glands as control tissue. Breast cancers categorized as ER(-)/HER2(-) revealed a high cDNA level of FABP-7 as compared to other groups of breast cancer (p=0.004). An immunohistochemical study carried out on 88 cases showed that FABP-7 overexpression had a strong relationship with triple-negative cases (45.8%, p=0.001) and the basal-like subtype (37.5%, p=0.001). Estrogen receptor (ER) and progesterone receptor (PgR) expressions had reverse correlation with FABP-7 overexpression (p=0.003, p<0.0001), but no significant associations can be identified between human epidermal growth factor receptor-2 (HER2) and FABP-7 (p=0.219). In conclusion, this study is the first to demonstrate overexpression of FABP-7 in triple-negative breast cancers [ER(-), PgR(-)/HER2(-)], especially in basal-like breast cancer, and to give a probable interpretation of the high histological grade and poor prognosis of basal-like breast cancer.
脂肪酸结合蛋白-7（FABP-7）通常在乳腺中表达。本研究旨在阐明 FABP-7 过表达的乳腺癌表型。对包括 4 例 ER（+）/HER2（-）、2 例 ER（+）/HER2（+）、3 例 ER（-）/HER2（+）和 5 例 ER（-）/HER2（-）在内的 16 例病例和 2 例非肿瘤性乳腺组织进行逆转录 PCR（RT-PCR）分析。与其他乳腺癌组相比，归类为 ER（-）/HER2（-）的乳腺癌的 FABP-7 cDNA 水平较高（p=0.004）。对 88 例病例进行的免疫组织化学研究表明，FABP-7 过表达与三阴性病例（45.8%，p=0.001）和基底样亚型（37.5%，p=0.001）具有很强的关系。雌激素受体（ER）和孕激素受体（PgR）的表达与 FABP-7 过表达呈负相关（p=0.003，p<0.0001），但人类表皮生长因子受体-2（HER2）与 FABP-7 之间没有明显的关联（p=0.219）。总之，本研究首次证明 FABP-7 在三阴性乳腺癌（ER（-）、PgR（-）/HER2（-））中过表达，尤其是在基底样乳腺癌中，并且可能解释了基底样乳腺癌的高组织学分级和预后不良。
