Faculty of Health and Social Care Sciences, Kingston University and St George's, London, UK.
Eur Respir J. 2009 Dec;34(6):1322-8. doi: 10.1183/09031936.00044009. Epub 2009 Jul 16.
Increased large artery stiffness occurs in a range of inflammatory conditions indicating an ageing of the vasculature and additionally being an independent risk factor for cardiovascular events. We determined large artery parameters in adults with cystic fibrosis (CF). 50 clinically stable adult patients with CF (mean+/-sd age 28.0+/-8.2 yrs) and 26 controls matched for age, sex and body mass index were studied. Central aortic blood pressure, augmentation index (AIx) and aortic pulse wave velocity (PWV) were determined using applanation tonometry. Lung function, diabetic status and C-reactive protein (CRP) were also determined. Mean+/-sd AIx was greater in patients than controls, 8.5+/-11.1% and -1.8+/-13.1%, respectively (p<0.001), while PWV was similar. Although AIx was greatest in the sub-group with CF-related diabetes (CFRD), it was also increased in the non-CFRD sub-group when compared with controls. In patients, AIx was related to log(10) CRP (r = 0.33) and forced vital capacity (r = -0.34; both p<0.05), and CRP remained predictive in multiple regression. AIx is increased in adults with CF, in the presence of a normal blood pressure and independent of diabetic status. AIx was related to the systemic inflammatory status. These findings have implications for management and require further exploration so that cardiovascular health can be maintained.
大动脉僵硬度增加发生在一系列炎症性疾病中，表明血管老化，并且是心血管事件的独立危险因素。我们在囊性纤维化（CF）患者中确定了大动脉参数。研究了 50 名临床稳定的成年 CF 患者（平均年龄 28.0+/-8.2 岁）和 26 名年龄、性别和体重指数匹配的对照组。使用平板测压法测定主动脉中心血压、增强指数（AIx）和主动脉脉搏波速度（PWV）。还测定了肺功能、糖尿病状态和 C 反应蛋白（CRP）。患者的平均+/-sd AIx 大于对照组，分别为 8.5+/-11.1%和-1.8+/-13.1%（p<0.001），而 PWV 相似。尽管 AIx 在 CF 相关糖尿病（CFRD）亚组中最大，但与对照组相比，非 CFRD 亚组的 AIx 也增加了。在患者中，AIx 与 log(10)CRP（r = 0.33）和用力肺活量（r = -0.34；均 p<0.05）相关，CRP 在多元回归中仍然具有预测性。AIx 在 CF 成人中增加，血压正常且独立于糖尿病状态。AIx 与全身炎症状态有关。这些发现对管理具有影响，需要进一步探索，以维持心血管健康。
