Davis Daniel M
Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Nat Rev Immunol. 2009 Aug;9(8):543-55. doi: 10.1038/nri2602. Epub 2009 Jul 17.
Communication across intercellular contacts is central to establishing appropriate innate and adaptive immune responses. Recent imaging of lymphocyte interactions suggests that a complex orchestration of cell-cell contact times is a key correlate to establishing appropriate immune responses. Here I review the molecular and cellular processes that influence the duration of intercellular contacts, including integrin activation and dynamic changes in membrane morphology. I discuss how these processes can be regulated, for example, by the balance of activating and inhibitory receptor signals, and how they can establish the appropriate outcome for individual cell-cell interactions.
细胞间接触的通讯对于建立适当的先天性和适应性免疫反应至关重要。最近对淋巴细胞相互作用的成像表明，细胞间接触时间的复杂编排是建立适当免疫反应的关键相关因素。在这里，我回顾了影响细胞间接触持续时间的分子和细胞过程，包括整合素激活和膜形态的动态变化。我讨论了这些过程如何例如通过激活和抑制性受体信号的平衡来调节，以及它们如何为单个细胞间相互作用建立适当的结果。
