Notch与p53和p63在癌症生长控制中的相互作用。
Crosstalk of Notch with p53 and p63 in cancer growth control.
作者信息
Dotto G Paolo
机构信息
Department of Biochemistry, University of Lausanne, Epalinges CH-1066, Switzerland.
出版信息
Nat Rev Cancer. 2009 Aug;9(8):587-95. doi: 10.1038/nrc2675. Epub 2009 Jul 16.
Abstract
Understanding the complexity of cancer depends on an elucidation of the underlying regulatory networks, at the cellular and intercellular levels and in their temporal dimension. This Opinion article focuses on the multilevel crosstalk between the Notch pathway and the p53 and p63 pathways. These two coordinated signalling modules are at the interface of external damaging signals and control of stem cell potential and differentiation. Positive or negative reciprocal regulation of the two pathways can vary with cell type and cancer stage. Therefore, selective or combined targeting of the two pathways could improve the efficacy and reduce the toxicity of cancer therapies.
摘要
了解癌症的复杂性取决于在细胞和细胞间水平以及其时间维度上阐明潜在的调控网络。这篇观点文章聚焦于Notch信号通路与p53和p63信号通路之间的多级串扰。这两个协调的信号模块处于外部损伤信号与干细胞潜能及分化控制的界面。两条信号通路的正向或负向相互调控会因细胞类型和癌症阶段而异。因此，对这两条信号通路进行选择性或联合靶向治疗可能会提高癌症治疗的疗效并降低毒性。
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