匹西霉素及其N-乙酰半胱氨酸加合物由链霉菌属GB 4-2产生。
Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.
作者信息
Schulz Dirk, Nachtigall Jonny, Riedlinger Julia, Schneider Kathrin, Poralla Karl, Imhoff Johannes F, Beil Winfried, Nicholson Graeme, Fiedler Hans-Peter, Süssmuth Roderich D
机构信息
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
出版信息
J Antibiot (Tokyo). 2009 Sep;62(9):513-8. doi: 10.1038/ja.2009.64. Epub 2009 Jul 17.
Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B.
匹西霉素是一种新型的大环内酯聚酮类抗生素，通过高效液相色谱-二极管阵列筛选法在从挪威云杉菌根际分离得到的链霉菌属GB 4-2菌株的提取物中检测到。匹西霉素的结构通过质谱和核磁共振实验确定。它对革兰氏阳性菌、选定的人类肿瘤细胞系以及蛋白酪氨酸磷酸酶1B具有抑制活性。
Zotero 插件