Rohrschneider K, Koch H R
Abteilung für Mikrochirurgie des Auges, Universität Bonn.
Klin Monbl Augenheilkd. 1991 Aug;199(2):79-83. doi: 10.1055/s-2008-1046052.
In view of personal clinical observations, it appeared possible that a therapy with the carboanhydrase inhibitor acetazolamide leads to a reduction of tear production and induces a dry eye syndrome. Tear secretion was therefore measured by Schirmer tests in a control group of 66 patients after cataract surgery and in a test group of 20 patients who were treated with acetazolamide (Diamox, Glaupax) on the day after the cataract operation. The results were subjected to a statistical analysis with 3-factor anova. The cataract operation induced a significant increase of tear flow. Independent of this effect, administration of the carboanhydrase inhibitor caused a significant decrease of tear production, both in the operated eyes and the untouched fellow eyes.
基于个人临床观察，碳酸酐酶抑制剂乙酰唑胺疗法似乎有可能导致泪液分泌减少并诱发干眼症。因此，通过施密特试验对66例白内障手术后的患者对照组以及20例在白内障手术后次日接受乙酰唑胺（醋氮酰胺、格隆帕克斯）治疗的患者试验组进行泪液分泌测量。结果采用三因素方差分析进行统计分析。白内障手术导致泪液流量显著增加。与该效应无关的是，碳酸酐酶抑制剂的给药导致手术眼和未受影响的对侧眼的泪液分泌均显著减少。
