Schroeder P, Calles C, Krutmann J
Institut fuer Umweltmedizinische Forschung (IUF) at the University of Duesseldorf, Duesseldorf, Germany.
Skin Therapy Lett. 2009 Jun;14(5):4-5.
Photoaging and skin damage that is caused by solar radiation is well known. We have recently learned that within the solar spectrum this damage not only results from ultraviolet (UV) radiation, but also from longer wavelengths, in particular near infrared radiation. Accordingly, infrared radiation (IR) has been shown to alter the collagen equilibrium of the dermal extracellular matrix in at least 2 ways: (1) by leading to an increased expression of the collagen degrading enzyme matrixmetalloproteinase-1 while (2) decreasing the de novo synthesis of the collagen itself. Infrared-A (IRA) radiation exposure, therefore, induces similar biological effects to UV, but the underlying mechanisms are substantially different. IRA acts via the mitochondria and therefore protection from IR requires alternative strategies.
由太阳辐射引起的光老化和皮肤损伤是众所周知的。我们最近了解到，在太阳光谱范围内，这种损伤不仅源于紫外线（UV）辐射，还源于更长的波长，特别是近红外辐射。因此，红外辐射（IR）已被证明至少以两种方式改变真皮细胞外基质的胶原蛋白平衡：（1）导致胶原蛋白降解酶基质金属蛋白酶-1的表达增加，同时（2）减少胶原蛋白本身的从头合成。因此，红外-A（IRA）辐射暴露会诱导与紫外线相似的生物学效应，但潜在机制却大不相同。IRA通过线粒体起作用，因此防止红外辐射需要采用替代策略。
