German Institute of Human Nutrition Potsdam-Rehbruecke, 14558, Nuthetal, Germany,
Genes Nutr. 2009 Sep;4(3):161-3. doi: 10.1007/s12263-009-0131-8. Epub 2009 Jul 16.
All definitions of the terms 'oxidative stress' and 'antioxidants' implicate that oxidants are just damaging. However, there is increasing evidence that reactive oxygen species (ROS) are not only toxic but that we need them for healthy life. This change in paradigm has been discussed at the third international symposium on 'Nutrition, oxygen biology and medicine-micronutrients, exercise, energy and aging disorders', of the Society for Free Radical Research France and the Oxygen Club of California on April 8-10, 2009 in Paris. The beneficial effect of a low to moderate concentration of oxidants produced during exercise was taken as most discussed example. In this case, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptation in endurance performance, as well as for the induction of endogenous defense systems. Taking antioxidants during training prevents adaptation. Although substantial progress on the understanding of the physiological functions of ROS was communicated at the meeting, it remained obvious that a lot of work is needed to fully understand the conditions and individual situations under which ROS are beneficial or detrimental.
所有关于“氧化应激”和“抗氧化剂”术语的定义都暗示氧化剂只是具有破坏性。然而，越来越多的证据表明，活性氧（ROS）不仅有毒，而且我们的健康生活也需要它们。这种范式的转变在 2009 年 4 月 8 日至 10 日于巴黎举行的法国自由基研究学会和加利福尼亚氧气俱乐部第三届“营养、氧气生物学与医学-微量营养素、运动、能量与衰老障碍”国际研讨会上进行了讨论。作为讨论最多的例子，人们研究了运动过程中产生的低浓度至中等浓度氧化剂的有益作用。在这种情况下，ROS 是骨骼肌正常产生力、耐力表现训练诱导适应发展以及内源性防御系统诱导所必需的。在训练期间服用抗氧化剂会阻止适应。尽管会议传达了对 ROS 生理功能理解的重大进展，但显然仍需要做大量工作，以充分了解 ROS 有益或有害的条件和个体情况。
