School of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima 15021, Peru.
School of Biology, Universidad Nacional Federico Villarreal, Lima 15088, Peru.
Biomolecules. 2023 Oct 31;13(11):1598. doi: 10.3390/biom13111598.
Anthocyanins are a type of flavonoids that give plants and fruits their vibrant colors. They are known for their potent antioxidant properties and have been linked to various health benefits. Upon consumption, anthocyanins are quickly absorbed and can penetrate the blood-brain barrier (BBB). Research based on population studies suggests that including anthocyanin-rich sources in the diet lower the risk of neurodegenerative diseases. Anthocyanins exhibit neuroprotective effects that could potentially alleviate symptoms associated with such diseases. In this review, we compiled and discussed a large body of evidence supporting the neuroprotective role of anthocyanins. Our examination encompasses human studies, animal models, and cell cultures. We delve into the connection between anthocyanin bioactivities and the mechanisms underlying neurodegeneration. Our findings highlight how anthocyanins' antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to their neuroprotective effects. These effects are particularly relevant to key signaling pathways implicated in the development of Alzheimer's and Parkinson's diseases. In conclusion, the outcome of this review suggests that integrating anthocyanin-rich foods into human diets could potentially serve as a therapeutic approach for neurological conditions, and we identify promising avenues for further exploration in this area.
花色苷是一类赋予植物和水果鲜艳颜色的类黄酮。它们以其强大的抗氧化特性而闻名,并与各种健康益处相关联。食用后,花色苷可迅速被吸收,并能穿透血脑屏障 (BBB)。基于人群研究的结果表明,在饮食中包含富含花色苷的食物可以降低神经退行性疾病的风险。花色苷具有神经保护作用,可能有助于缓解与这些疾病相关的症状。在这篇综述中,我们汇集并讨论了大量支持花色苷神经保护作用的证据。我们的研究涵盖了人体研究、动物模型和细胞培养。我们深入探讨了花色苷生物活性与神经退行性变机制之间的联系。我们的研究结果强调了花色苷的抗氧化、抗炎和抗细胞凋亡特性如何有助于其神经保护作用。这些作用对于阿尔茨海默病和帕金森病等疾病发展中涉及的关键信号通路尤为重要。总之,本综述的结果表明,将富含花色苷的食物纳入人类饮食中可能是治疗神经疾病的一种方法,我们确定了这一领域进一步探索的有前景的途径。