Beno J M, Nemeth D R
Office of the Medical Examiner, Rochester, New York 14620.
J Anal Toxicol. 1991 Sep-Oct;15(5):285-7. doi: 10.1093/jat/15.5.285.
A fatality resulting from the suicidal ingestion of diltiazem and metoclopramide is described. The decedent was a 25-year-old female with a history of alcoholism and cocaine abuse who overdosed on her mother's medications. On admission she was bradycardiac with severe hypotension and third-degree heart block which progressed to asystole. She was resuscitated but remained comatose until her death four days later. Serum samples from the first 15 h of hospitalization were analyzed for diltiazem and metoclopramide by gas chromatography with nitrogen-phosphorus detection. Diltiazem levels 1 hour post admission were 8.49 mg/L. Diltiazem elimination followed zero-order kinetics with an elimination rate of 0.68 mg/L/h. Metoclopramide levels 1 hour post admission were 4.4 mg/L. Data indicated a biphasic elimination curve for metoclopramide with an initial half-life of 1.3 h and a terminal half-life of 20 h.
描述了一例因自杀性摄入地尔硫卓和甲氧氯普胺导致的死亡病例。死者为一名25岁女性，有酗酒和滥用可卡因史，过量服用了其母亲的药物。入院时，她出现心动过缓，伴有严重低血压和三度心脏传导阻滞，进而发展为心搏停止。她被复苏，但一直昏迷，直至四天后死亡。通过氮磷检测气相色谱法对住院最初15小时的血清样本进行地尔硫卓和甲氧氯普胺分析。入院后1小时地尔硫卓水平为8.49mg/L。地尔硫卓的消除遵循零级动力学，消除速率为0.68mg/L/h。入院后1小时甲氧氯普胺水平为4.4mg/L。数据表明甲氧氯普胺的消除曲线为双相，初始半衰期为1.3小时，终末半衰期为20小时。
