Harris Steven D, Turner Geoffrey, Meyer Vera, Espeso Eduardo A, Specht Thomas, Takeshita Norio, Helmstedt Kerstin
Department of Plant Pathology and Center for Plant Science Innovation, University of Nebraska, E126 Beadle Center, Lincoln, NE 68588-0660, USA.
Fungal Genet Biol. 2009 Mar;46 Suppl 1:S82-S92. doi: 10.1016/j.fgb.2008.07.023.
Like other filamentous fungi, Aspergillus nidulans forms a multitude of cell types that facilitate colonization and development. The molecular basis of cellular morphogenesis in A. nidulans is not well understood.Here, we summarize results obtained from detailed annotation of the A. nidulans genome sequence for genes with predicted roles in morphogenesis, with primary focus on polarized growth, calcium signaling, and development. We draw three broad conclusions from our results. First, the components of the signal transduction pathways and morphogenetic machinery as defined in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are largely conserved in A. nidulans. Second,A. nidulans possesses many additional genes implicated in morphogenesis that are not conserved in these yeasts. Third, the number of A. nidulans genes involved in morphogenesis is likely to be rather large;based on our annotation, we estimate that as many as 2000 A. nidulans genes encode proteins that may participate at some level in morphogenesis during vegetative growth and development.
与其他丝状真菌一样，构巢曲霉会形成多种细胞类型，以促进定殖和发育。目前对构巢曲霉细胞形态发生的分子基础了解尚少。在此，我们总结了对构巢曲霉基因组序列进行详细注释后，在形态发生中具有预测作用的基因所得到的结果，主要集中在极性生长、钙信号传导和发育方面。我们从结果中得出了三个广泛的结论。第一，模式酵母酿酒酵母和粟酒裂殖酵母中定义的信号转导途径和形态发生机制的组成部分在构巢曲霉中基本保守。第二，构巢曲霉拥有许多其他与形态发生有关的基因，这些基因在这些酵母中并不保守。第三，构巢曲霉中参与形态发生的基因数量可能相当多；根据我们的注释，我们估计多达2000个构巢曲霉基因编码的蛋白质可能在营养生长和发育过程中的某个水平参与形态发生。
