• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗氧化剂愈创木酚对[具体名称未给出]中的真菌生长和脱氧雪腐镰刀菌烯醇产生具有杀菌活性。

The Antioxidant Guaiacol Exerts Fungicidal Activity Against Fungal Growth and Deoxynivalenol Production in .

作者信息

Gao Tao, Zhang Yao, Shi Jianrong, Mohamed Sherif Ramzy, Xu Jianhong, Liu Xin

机构信息

Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Key Laboratory for Control Technology and Standard for Agro-Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

出版信息

Front Microbiol. 2021 Nov 15;12:762844. doi: 10.3389/fmicb.2021.762844. eCollection 2021.

DOI:10.3389/fmicb.2021.762844
PMID:34867894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8634675/
Abstract

The main component of creosote obtained from dry wood distillation-guaiacol-is a natural antioxidant that has been widely used in pharmaceutical and food preservation applications. However, the antifungal mechanism of guaiacol against phytopathogens remains unclear. In this study, we found that guaiacol exerts inhibitory effects against mycelial growth, conidial formation and germination, and deoxynivalenol (DON) biosynthesis in in a dose-dependent manner. The median effective concentration (EC) value of guaiacol for the standard strain PH-1 was 1.838 mM. Guaiacol strongly inhibited conidial production and germination. The antifungal effects of guaiacol may be attributed to its capability to cause damage to the cell membrane by disrupting Ca transport channels. In addition, the decreased malondialdehyde (MDA) levels and catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activity by guaiacol treatment indicate that guaiacol displays activity against DON production by modulating the oxidative response in Taken together, this study revealed the potentials of antioxidant in inhibiting mycotoxins in .

摘要

通过干馏木材获得的杂酚油的主要成分——愈创木酚，是一种天然抗氧化剂，已广泛应用于制药和食品保鲜领域。然而，愈创木酚对植物病原体的抗真菌机制仍不清楚。在本研究中，我们发现愈创木酚对菌丝体生长、分生孢子形成和萌发以及脱氧雪腐镰刀菌烯醇（DON）生物合成具有剂量依赖性抑制作用。愈创木酚对标准菌株PH-1的半数有效浓度（EC）值为1.838 mM。愈创木酚强烈抑制分生孢子的产生和萌发。愈创木酚的抗真菌作用可能归因于其通过破坏钙转运通道对细胞膜造成损伤的能力。此外，愈创木酚处理降低了丙二醛（MDA）水平以及过氧化氢酶（CAT）、过氧化物酶（POD）和超氧化物歧化酶（SOD）的活性，这表明愈创木酚通过调节氧化反应对DON产生具有活性。综上所述，本研究揭示了抗氧化剂在抑制[具体研究对象未明确写出]中霉菌毒素方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/2027883b5e0b/fmicb-12-762844-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/6912a11eb282/fmicb-12-762844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/7105407ea6ac/fmicb-12-762844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/69897f963140/fmicb-12-762844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/18daff137dce/fmicb-12-762844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/354c3bc0bdc2/fmicb-12-762844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/8f5769c6e941/fmicb-12-762844-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/2027883b5e0b/fmicb-12-762844-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/6912a11eb282/fmicb-12-762844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/7105407ea6ac/fmicb-12-762844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/69897f963140/fmicb-12-762844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/18daff137dce/fmicb-12-762844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/354c3bc0bdc2/fmicb-12-762844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/8f5769c6e941/fmicb-12-762844-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a24/8634675/2027883b5e0b/fmicb-12-762844-g007.jpg

相似文献

1
The Antioxidant Guaiacol Exerts Fungicidal Activity Against Fungal Growth and Deoxynivalenol Production in .抗氧化剂愈创木酚对[具体名称未给出]中的真菌生长和脱氧雪腐镰刀菌烯醇产生具有杀菌活性。
Front Microbiol. 2021 Nov 15;12:762844. doi: 10.3389/fmicb.2021.762844. eCollection 2021.
2
The Fungicidal Activity of Thymol against Fusarium graminearum via Inducing Lipid Peroxidation and Disrupting Ergosterol Biosynthesis.百里香酚通过诱导脂质过氧化和破坏麦角甾醇生物合成对禾谷镰刀菌的杀菌活性
Molecules. 2016 Jun 18;21(6):770. doi: 10.3390/molecules21060770.
3
Antifungal Activity of Quinofumelin against and Its Inhibitory Effect on DON Biosynthesis.新型化合物喹诺氟林抗和对 DON 生物合成的抑制作用。
Toxins (Basel). 2021 May 12;13(5):348. doi: 10.3390/toxins13050348.
4
Limonene formulation exhibited potential application in the control of mycelial growth and deoxynivalenol production in .柠檬烯制剂在控制[具体对象]的菌丝生长和脱氧雪腐镰刀菌烯醇产生方面显示出潜在应用。
Front Microbiol. 2023 Mar 23;14:1161244. doi: 10.3389/fmicb.2023.1161244. eCollection 2023.
5
[Inhibition of Fusarium graminearum by silver nanoparticles].[银纳米颗粒对禾谷镰刀菌的抑制作用]
Sheng Wu Gong Cheng Xue Bao. 2017 Apr 25;33(4):620-629. doi: 10.13345/j.cjb.160375.
6
Study on the fungicidal mechanism of glabridin against Fusarium graminearum.研究甘草素对禾谷镰刀菌的杀菌机制。
Pestic Biochem Physiol. 2021 Nov;179:104963. doi: 10.1016/j.pestbp.2021.104963. Epub 2021 Sep 10.
7
2-Hydroxy-4-methoxybenzaldehyde, a more effective antifungal aroma than vanillin and its derivatives against , destroys cell membranes, inhibits DON biosynthesis, and performs a promising antifungal effect on wheat grains.2-羟基-4-甲氧基苯甲醛是一种比香草醛及其衍生物对[某种真菌]更有效的抗真菌香气物质，它会破坏细胞膜，抑制脱氧雪腐镰刀菌烯醇（DON）的生物合成，并对小麦籽粒具有良好的抗真菌效果。
Front Microbiol. 2024 Feb 26;15:1359947. doi: 10.3389/fmicb.2024.1359947. eCollection 2024.
8
The Dynamin-Like GTPase FgSey1 Plays a Critical Role in Fungal Development and Virulence in Fusarium graminearum.Dynamin 样 GTP 酶 FgSey1 在禾谷镰刀菌的真菌发育和毒力中发挥关键作用。
Appl Environ Microbiol. 2020 May 19;86(11). doi: 10.1128/AEM.02720-19.
9
Trehalose-6-phosphate phosphatase inhibitor: N-(phenylthio) phthalimide, which can inhibit the DON biosynthesis of Fusarium graminearum.海藻糖-6-磷酸磷酸酶抑制剂：N-(苯硫基)邻苯二甲酰亚胺，可抑制禾谷镰刀菌 DON 的生物合成。
Pestic Biochem Physiol. 2021 Oct;178:104917. doi: 10.1016/j.pestbp.2021.104917. Epub 2021 Jul 9.
10
The Fungicidal Activity of Tebuconazole Enantiomers against Fusarium graminearum and Its Selective Effect on DON Production under Different Conditions.戊唑醇对映体对禾谷镰刀菌的杀菌活性及其在不同条件下对 DON 产生的选择性影响。
J Agric Food Chem. 2018 Apr 11;66(14):3637-3643. doi: 10.1021/acs.jafc.7b05483. Epub 2018 Mar 26.

引用本文的文献

1
Using WGCNA and transcriptome profiling to identify hub genes for salt stress tolerance in germinating soybean seeds.利用加权基因共表达网络分析（WGCNA）和转录组分析来鉴定萌发大豆种子中耐盐胁迫的关键基因。
Front Plant Sci. 2025 Aug 8;16:1569565. doi: 10.3389/fpls.2025.1569565. eCollection 2025.
2
Comparative Phytochemical Analysis and Antimicrobial Properties of Ethanol and Macerated Extracts from Aerial and Root Parts of ..地上部分和根部乙醇提取物与浸渍提取物的比较植物化学分析及抗菌特性
Molecules. 2025 Jul 14;30(14):2957. doi: 10.3390/molecules30142957.
3
Pyrolysis of Rice Husk for the Production of Bioactive Compounds with Potential in Green Chemistry and Sustainable Agriculture.

本文引用的文献

1
Quinone outside inhibitors affect DON biosynthesis, mitochondrial structure and toxisome formation in Fusarium graminearum.醌外部抑制剂影响禾谷镰刀菌中脱氧雪腐镰刀菌烯醇的生物合成、线粒体结构和毒素体形成。
J Hazard Mater. 2020 Nov 5;398:122908. doi: 10.1016/j.jhazmat.2020.122908. Epub 2020 May 15.
2
Pathogenomics and Management of Diseases in Plants.植物病害的病原基因组学与管理
Pathogens. 2020 May 1;9(5):340. doi: 10.3390/pathogens9050340.
3
Wheat straw vinegar: A more cost-effective solution than chemical fungicides for sustainable wheat plant protection.
稻壳热解制备具有绿色化学和可持续农业潜力的生物活性化合物
Molecules. 2025 Jun 26;30(13):2754. doi: 10.3390/molecules30132754.
4
An Innovative Method of Obtaining Herbal Propolis Extracts and Application of its Spray-Dried Form as Natural Food Preservatives.一种获取草药蜂胶提取物的创新方法及其喷雾干燥形式作为天然食品防腐剂的应用。
Int J Food Sci. 2025 Jun 28;2025:5546802. doi: 10.1155/ijfo/5546802. eCollection 2025.
5
Exploring Morphological, Transcriptomic, and Metabolomic Differences Between Two Sister Lines with Contrasting Resistance to Orange Rust Disease in Sugarcane.探索甘蔗中对橙色锈病抗性不同的两个姊妹系之间的形态学、转录组学和代谢组学差异。
Int J Mol Sci. 2025 Apr 8;26(8):3490. doi: 10.3390/ijms26083490.
6
In vitro activity of seven antifungal agents against Fusarium oxysporum and expression of related regulatory genes.七种抗真菌剂对尖孢镰刀菌的体外活性及相关调控基因的表达
PLoS One. 2025 Apr 29;20(4):e0322206. doi: 10.1371/journal.pone.0322206. eCollection 2025.
7
Fractional inhibitory concentration of bio-actives from agricultural waste disassembles biofilms and quenches virulence of nosocomial pathogens.农业废弃物生物活性成分的分数抑制浓度可分解生物膜并消除医院病原体的毒力。
J Med Microbiol. 2025 Mar;74(3). doi: 10.1099/jmm.0.001980.
8
Proteomic Analysis of Plants with Binding Immunoglobulin Protein Overexpression Reveals Mechanisms Related to Defense Against .对具有结合免疫球蛋白蛋白过表达的植物进行蛋白质组学分析揭示了与抵御……相关的机制。
Plants (Basel). 2025 Feb 7;14(4):503. doi: 10.3390/plants14040503.
9
Pisco, an Appellation of Origin from Peru: A review.皮斯科，秘鲁的一个原产地名称：综述。
Heliyon. 2025 Jan 24;11(3):e42251. doi: 10.1016/j.heliyon.2025.e42251. eCollection 2025 Feb 15.
10
Turmeric-Black Cumin Essential Oils and Their Capacity to Attenuate Free Radicals, Protein Denaturation, and Cancer Proliferation.姜黄-黑孜然精油及其减轻自由基、蛋白质变性和抑制癌细胞增殖的能力。
Molecules. 2024 Jul 26;29(15):3523. doi: 10.3390/molecules29153523.
小麦秸秆醋液：一种比化学杀菌剂更具成本效益的可持续小麦植物保护解决方案。
Sci Total Environ. 2020 Jul 10;725:138359. doi: 10.1016/j.scitotenv.2020.138359. Epub 2020 Apr 2.
4
Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-κB, MAPK and AKT pathways.愈创木酚通过阻断RANK与TRAF6和C-Src的相互作用以及抑制NF-κB、MAPK和AKT信号通路来抑制破骨细胞生成。
J Cell Mol Med. 2020 May;24(9):5122-5134. doi: 10.1111/jcmm.15153. Epub 2020 Mar 17.
5
Resistance risk assessment for Fusarium graminearum to pydiflumetofen, a new succinate dehydrogenase inhibitor.小麦赤霉病菌对琥珀酸脱氢酶抑制剂吡唑醚菌酯的抗药性风险评估。
Pest Manag Sci. 2020 Apr;76(4):1549-1559. doi: 10.1002/ps.5675. Epub 2019 Dec 11.
6
Trichothecene Mycotoxins: Biosynthesis, Regulation, and Management.麦角生物碱生物合成、调控和管理。
Annu Rev Phytopathol. 2019 Aug 25;57:15-39. doi: 10.1146/annurev-phyto-082718-100318. Epub 2019 Mar 20.
7
Guaiacol as a drug candidate for treating adult polyglucosan body disease.愈创木酚作为治疗成年多聚糖体病的候选药物。
JCI Insight. 2018 Sep 6;3(17). doi: 10.1172/jci.insight.99694.
8
The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in by Modulating Transcription Factors FarB and CreA.抗氧化剂没食子酸通过调节转录因子 FarB 和 CreA 抑制在 中的黄曲霉毒素形成。
Toxins (Basel). 2018 Jul 3;10(7):270. doi: 10.3390/toxins10070270.
9
Antibacterial and antifungal activities of pyroligneous acid from wood of Eucalyptus urograndis and Mimosa tenuiflora.桉树木材和含羞草木醋液的抑菌和抗真菌活性。
J Appl Microbiol. 2018 Jan;124(1):85-96. doi: 10.1111/jam.13626. Epub 2017 Dec 19.
10
Metabolic regulation of the PMCA: Role in cell death and survival.PMCA 的代谢调控：在细胞死亡和存活中的作用。
Cell Calcium. 2018 Jan;69:28-36. doi: 10.1016/j.ceca.2017.06.001. Epub 2017 Jun 8.