Jeffreys A J, MacLeod A, Tamaki K, Neil D L, Monckton D G
Department of Genetics, University of Leicester, UK.
Nature. 1991 Nov 21;354(6350):204-9. doi: 10.1038/354204a0.
Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple alternative approach that displays patterns of variant repeat units along minisatellite alleles is described here. This produces DNA profiles as extraordinarily variable digital sequences appropriate for forensic investigations, including computer databasing, and for analysing allele diversity and the role of recombination in minisatellite instability.
法医和法医学中使用的大多数DNA分型系统检测串联重复DNA区域(如小卫星)的等位基因长度变异。本文描述了一种简单的替代方法,该方法可显示小卫星等位基因上变异重复单元的模式。这会产生作为非常可变的数字序列的DNA图谱,适用于法医调查,包括计算机数据库,以及分析等位基因多样性和重组在小卫星不稳定性中的作用。