真核生物中水平基因转移的预测：方法与挑战。

Prediction of horizontal gene transfers in eukaryotes: approaches and challenges.

作者信息

Whitaker John W, McConkey Glenn A, Westhead David R

机构信息

Institute of Molecular and Cellular Biology, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK.

出版信息

Biochem Soc Trans. 2009 Aug;37(Pt 4):792-5. doi: 10.1042/BST0370792.

DOI:10.1042/BST0370792

PMID:19614596

Abstract

HGT (horizontal gene transfer) is recognized as an important force in bacterial evolution. Now that many eukaryotic genomes have been sequenced, it has become possible to carry out studies of HGT in eukaryotes. The present review compares the different approaches that exist for identifying HGT genes and assess them in the context of studying eukaryotic evolution. The metabolic evolution resource metaTIGER is then described, with discussion of its application in identification of HGT in eukaryotes.

摘要

水平基因转移（HGT）被认为是细菌进化中的一种重要力量。既然许多真核生物基因组已被测序，那么对真核生物中的水平基因转移进行研究就成为可能。本综述比较了用于识别水平基因转移基因的不同方法，并在研究真核生物进化的背景下对这些方法进行了评估。随后介绍了代谢进化资源metaTIGER，并讨论了其在真核生物水平基因转移识别中的应用。