Yoon Yeong Sook, Park Hye Soon, Yun Kyung Eun, Kim Soon Bae
Department of Family Medicine, Ilsan Paik Hospital, University of Inje College of Medicine. Gyeonggi-do 410-706, South Korea.
Metabolism. 2009 Dec;58(12):1737-42. doi: 10.1016/j.metabol.2009.05.029. Epub 2009 Jul 16.
Metabolic syndrome (MS) is associated with chronic kidney disease (CKD). The objective of this study is to examine the association between obesity and MS-related CKD in nondiabetic, nonhypertensive Korean adults. Korea National Health and Nutrition Examination Survey III data from 3771 nondiabetic, nonhypertensive Koreans were analyzed. Metabolic syndrome was defined according to the National Cholesterol Education Program-Adult Treatment Panel III, and CKD was diagnosed at an estimated glomerular filtration rate less than 60 mL/(min 1.73 m(2)). The crude and multivariate-adjusted odds ratios (ORs) of CKD associated with MS and its individual components were calculated using logistic regression models in a study population stratified by obesity. The prevalence of MS and CKD was 13.4% and 3.2%, respectively. The association between MS and CKD was significant in obese (OR, 2.91; 95% confidence interval [CI] = 1.34-6.34), but not nonobese (OR, 1.38; 95% CI = 0.60-3.17), subjects. In obese subjects, impaired fasting glucose (OR, 2.47; 95% CI = 1.10-5.57) and high triglyceride levels (OR, 2.42; 95% CI = 1.01-5.83) were risk factors for CKD, whereas no components were significantly associated with CKD in nonobese subjects. Our findings suggest that even in nondiabetic, nonhypertensive Korean adults, early detection and prevention of CKD in obese subjects with MS are critical.
代谢综合征（MS）与慢性肾脏病（CKD）相关。本研究的目的是在非糖尿病、非高血压的韩国成年人中，探讨肥胖与MS相关的CKD之间的关联。分析了来自韩国国家健康与营养检查调查III的3771名非糖尿病、非高血压韩国人的数据。代谢综合征根据美国国家胆固醇教育计划成人治疗小组III进行定义，CKD诊断为估计肾小球滤过率低于60 mL/（min·1.73 m²）。在按肥胖分层的研究人群中，使用逻辑回归模型计算与MS及其各个组分相关的CKD的粗比值比（OR）和多变量调整后的OR。MS和CKD的患病率分别为13.4%和3.2%。在肥胖受试者中，MS与CKD之间存在显著关联（OR，2.91；95%置信区间[CI]=1.34 - 6.34），但在非肥胖受试者中无显著关联（OR，1.38；95% CI = 0.60 - 3.17）。在肥胖受试者中，空腹血糖受损（OR，2.47；95% CI = 1.10 - 5.57）和高甘油三酯水平（OR，2.42；95% CI = 1.01 - 5.83）是CKD的危险因素，而在非肥胖受试者中，无组分与CKD显著相关。我们的研究结果表明，即使在非糖尿病、非高血压的韩国成年人中，对患有MS的肥胖受试者进行CKD的早期检测和预防也至关重要。
