Mendrone Alfredo, Arrais Cyntia Araújo, Almeida Neto César, Gualandro Sandra de Fátima Menocci, Dorlhiac-Llacer Pedro Enrique, Chamone Dalton de Alencar Fischer, Sabino Ester Cerdeira
Fundação Pró-Sangue/Hemocentro de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, Cerqueira Cesar, 05403-000 São Paulo, SP, Brazil.
Transfus Apher Sci. 2009 Aug;41(1):13-7. doi: 10.1016/j.transci.2009.05.002. Epub 2009 Jul 16.
One limiting factor for automated two-red blood cells collections (2-RBC) is its potential iron depletion. We analyzed hematological parameters and iron balance before, two and four months after 2-RBC of 96 non-supplemented male donors. Four months after 2-RBC, ferritin level was significantly lower (P<0.01) than baseline levels and the number of donors who presented ferritin <30 ng/ml increased from 18 to 47. We concluded that four months was not sufficient for iron recuperation in the population studied. In an attempt to avoid iron depletion after 2-RBC, we recommend augmentation in the interval between blood donations and pre-donation ferritin measurement.
自动采集双份红细胞（2-RBC）的一个限制因素是其潜在的铁耗竭。我们分析了96名未补充铁剂的男性献血者在进行2-RBC采集前、采集后两个月和四个月时的血液学参数及铁平衡情况。2-RBC采集四个月后，铁蛋白水平显著低于基线水平（P<0.01），铁蛋白<30 ng/ml的献血者人数从18人增加到47人。我们得出结论，在所研究的人群中，四个月的时间不足以使铁恢复。为避免2-RBC采集后出现铁耗竭，我们建议延长献血间隔并在献血前进行铁蛋白检测。
