半胱天冬酶底物与神经退行性疾病

Caspase substrates and neurodegenerative diseases.

作者信息

Bulat Natasa, Widmann Christian

机构信息

Department of Physiology, Lausanne University, 1005 Lausanne, Switzerland.

出版信息

Brain Res Bull. 2009 Oct 28;80(4-5):251-67. doi: 10.1016/j.brainresbull.2009.07.007. Epub 2009 Jul 16.

DOI:10.1016/j.brainresbull.2009.07.007

PMID:19616078

Abstract

Apoptosis is induced by the cleavage of a subset of cellular proteins by proteases of the caspase family. Numerous (hundreds) caspase substrates have been described but only for a few of them is the function of their cleavage by caspases well understood. In this review, apoptosis and caspases will first be introduced. The main focus will then be directed to the caspase substrates, the actual "workers" doing the job of mediating and regulating the apoptotic process. The caspase substrates whose functions upon cleavage have been carefully investigated and those that are potentially involved in neurodegenerative diseases will be discussed in detail.

摘要

细胞凋亡是由半胱天冬酶家族的蛋白酶切割细胞内一部分蛋白质所诱导的。已经描述了众多（数百种）半胱天冬酶底物，但只有少数几种底物被半胱天冬酶切割后的功能得到了充分了解。在本综述中，将首先介绍细胞凋亡和半胱天冬酶。然后，主要重点将转向半胱天冬酶底物，它们是介导和调节细胞凋亡过程的实际“执行者”。将详细讨论其切割后功能已被仔细研究以及可能与神经退行性疾病有关的半胱天冬酶底物。