Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, USA.
Nanomedicine. 2010 Apr;6(2):237-44. doi: 10.1016/j.nano.2009.07.001. Epub 2009 Jul 16.
This review describes the challenges and therapeutic applications of nanodelivery systems for treatment of airway diseases. Therapeutic applications of nanodelivery in airway diseases involve targeted delivery of DNA, short interfering RNA, drugs, or peptides to hematopoietic progenitor cells and pulmonary epithelium to control chronic pathophysiology of obstructive and conformational disorders. The major challenges to nanodelivery involve physiologic barriers such as mucus and alveolar fluid. It is necessary for the nanoparticles to be biodegradable and capable of providing sustained drug delivery to the selected cell type. Once inside the cell, the nanoparticle should be capable of escaping the endocytic degradation machinery. In addition, for effective gene delivery, nuclear entry and chromosomal integration are critical. The strategies to overcome these pathophysiologic barriers are discussed as an attempt to synchronize the efforts of pulmonary biologists, chemists, and clinicians to develop novel nanodelivery therapeutics for airway diseases.
Therapeutic applications of nano-delivery in airway diseases involve targeted delivery of DNA, siRNA, drugs or peptides to hematopoietic progenitor cells and pulmonary epithelium. These nano-particles must be biodegradable, capable of providing sustained drug delivery to specific cells, and should escape the endocytic degradation machinery. For effective gene-delivery they should also provide nuclear entry and chromosomal integration.
本综述描述了用于治疗气道疾病的纳米递药系统的挑战和治疗应用。纳米递药在气道疾病中的治疗应用涉及将 DNA、小干扰 RNA、药物或肽靶向递送至造血祖细胞和肺上皮细胞，以控制阻塞性和构象性疾病的慢性病理生理学。纳米递药的主要挑战涉及生理屏障，如黏液和肺泡液。纳米颗粒必须是可生物降解的，并能够向选定的细胞类型提供持续的药物递送。一旦进入细胞，纳米颗粒就应该能够逃脱内吞降解机制。此外，对于有效的基因递送，核进入和染色体整合是至关重要的。本文讨论了克服这些病理生理障碍的策略，试图将肺生物学家、化学家、临床医生的努力同步起来，为气道疾病开发新型的纳米递药治疗方法。
纳米递药在气道疾病中的治疗应用涉及将 DNA、siRNA、药物或肽靶向递送至造血祖细胞和肺上皮细胞。这些纳米颗粒必须是可生物降解的，能够向特定细胞提供持续的药物递送，并且应该逃脱内吞降解机制。对于有效的基因传递，它们还应该提供核进入和染色体整合。
