慢性精神分裂症的不良预后与壳核体积的逐渐丧失有关。
Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen.
作者信息
Mitelman Serge A, Canfield Emily L, Chu King-Wai, Brickman Adam M, Shihabuddin Lina, Hazlett Erin A, Buchsbaum Monte S
机构信息
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
Schizophr Res. 2009 Sep;113(2-3):241-5. doi: 10.1016/j.schres.2009.06.022. Epub 2009 Jul 18.
BACKGROUND
We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects.
METHODS
Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects.
RESULTS
Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups.
CONCLUSIONS
Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia.
背景
我们之前已经证明，在慢性精神分裂症患者中，壳核体积而非尾状核体积与不良预后相关。当前的纵向研究旨在调查不同预后的慢性精神分裂症患者与健康受试者之间纹状体体积的渐进性差异。
方法
在基线时以及四年后的随访时进行结构磁共振成像扫描，以评估26例预后不良的精神分裂症患者、23例预后良好的患者和16名健康受试者的体积变化。
结果
不同预后的精神分裂症患者进入研究时尾状核和壳核体积相似。预后不良的患者壳核体积下降速度比预后良好的组更快，因此在随访时他们的壳核体积而非尾状核体积显著更小。精神分裂症患者与健康对照受试者的壳核基线体积和随访体积及其进展速度均无差异。在基线和随访时，精神分裂症患者的尾状核体积均低于健康受试者，但两组之间未显示出不同的进展模式。
结论
壳核体积可能代表慢性精神分裂症患者治疗反应性和预后的纵向指标。
Zotero 插件