Luna Expedito J A, Veras Maria Amélia S M, Flannery Brendan, de Moraes José Cássio
Tropical Medicine Institute, University of São Paulo, São Paulo, Brazil.
Vaccine. 2009 Aug 27;27(39):5326-31. doi: 10.1016/j.vaccine.2009.06.096. Epub 2009 Jul 17.
We conducted a multi-stage household cluster survey to calculate hepatitis B vaccine coverage among children 18-30 months of age in 27 Brazilian cities. Hepatitis B vaccine is administered at birth, 1 month and 6 months of age by Brazil's national immunization program. Among 17,749 children surveyed, 40.2% received a birth dose within one day of birth, 94.8% received at least one dose of hepatitis B vaccine, and 86.7% completed the three-dose series by 12 months of age. Increased coverage with the birth dose and administration of hepatitis B in combination with diphtheria-tetanus-pertussis-Haemophilus influenzae type b antigens could improve protection against hepatitis B.
我们开展了一项多阶段家庭整群调查,以计算巴西27个城市中18至30月龄儿童的乙肝疫苗接种率。巴西国家免疫规划在出生时、1月龄和6月龄接种乙肝疫苗。在接受调查的17749名儿童中,40.2%在出生后一天内接种了首剂疫苗,94.8%至少接种了一剂乙肝疫苗,86.7%在12月龄时完成了三剂次全程接种。提高首剂疫苗接种率以及将乙肝疫苗与白喉-破伤风-百日咳- b型流感嗜血杆菌抗原联合接种,可增强对乙肝的预防效果。