哥伦比亚亚马逊地区高流行率且难以到达地区乙肝疫苗首剂接种的依从性:一项疫苗接种调查结果

Compliance with birth dose of Hepatitis B vaccine in high endemic and hard to reach areas in the Colombian amazon: results from a vaccination survey.

作者信息

Choconta-Piraquive Luz Angela, De la Hoz-Restrepo Fernando, Sarmiento-Limas Carlos Arturo

机构信息

Public Health Department, Universidad Nacional de Colombia, Bogotá, Colombia.

出版信息

BMC Health Serv Res. 2016 Jul 21;16:293. doi: 10.1186/s12913-016-1542-z.

Abstract

BACKGROUND

Hepatitis B vaccination was introduced into the Expanded Program of Immunization in Colombia in 1992, in response to WHO recommendations on hepatitis B immunization. Colombia is a low endemic country for Hepatitis B virus infection (HBV) but it has several high endemic areas like the Amazon basin where more than 70 % of adults had been infected. A cross- sectional study was carried out in three rural areas of the Colombian Amazon to evaluate compliance with the recommended schedule for hepatitis B vaccine in Colombian children (one monovalent dose given in the first 24 h after birth + 3 doses of a pentavalent containing Hepatitis B. (DPT + Hib + Hep B).

METHODS

A household survey was conducted in order to collect vaccination data from children aged from 6 months to <8 years. Vaccination status was related to sociodemographic data obtained from children caretakers.

RESULTS

Among 938 children above 6 months and < 8 years old studied, 79 % received a monovalent dose of hepatitis B vaccine, but only 30.7 % were vaccinated in the first 24 h after birth. This proportion did not increase by age or subsequent birth cohorts. Coverage with three doses of a DTP-Hib-HepB vaccine was 98 %, but most children did not receive them according to the recommended schedule. Being born in a health facility was the strongest predictor of receiving a timely birth dose.

CONCLUSIONS

This study suggests that more focused strategies on improving compliance with hepatitis B birth dose should be implemented in rural areas of the Amazon, if elimination of perinatal transmission of HBV is to be achieved. Increasing the proportion of newborns delivered at health facilities should be one of the priorities to reach that goal.

摘要

背景

1992年,根据世界卫生组织关于乙肝免疫接种的建议,乙肝疫苗被纳入哥伦比亚扩大免疫规划。哥伦比亚是乙肝病毒感染(HBV)的低流行国家,但有几个高流行地区,如亚马逊盆地,那里超过70%的成年人曾被感染。在哥伦比亚亚马逊地区的三个农村地区开展了一项横断面研究,以评估哥伦比亚儿童乙肝疫苗推荐接种程序的依从性(出生后24小时内接种一剂单价疫苗 + 3剂含乙肝疫苗的五联疫苗(白百破 + Hib + 乙肝))。

方法

进行了一项家庭调查,以便收集6个月至未满8岁儿童的疫苗接种数据。疫苗接种状况与从儿童看护人处获得的社会人口学数据相关。

结果

在研究的938名6个月以上至未满8岁的儿童中,79%接种了一剂单价乙肝疫苗,但只有30.7%在出生后24小时内接种。这一比例并未随年龄或后续出生队列增加。三剂白百破-Hib-乙肝疫苗的接种覆盖率为98%,但大多数儿童未按照推荐程序接种。在医疗机构出生是及时接种出生剂量疫苗的最强预测因素。

结论

本研究表明,如果要实现消除HBV围产期传播,应在亚马逊农村地区实施更有针对性的策略,以提高乙肝出生剂量疫苗的接种依从性。提高在医疗机构分娩的新生儿比例应是实现该目标的优先事项之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e81/4955212/60e4bd7dd75c/12913_2016_1542_Fig1_HTML.jpg

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