Müller-Limmroth W, Ehrenstein W
Med Klin. 1977 Jun 24;72(25):1119-25.
Seda-Kneipp a compound preparation of valerian and hops was given to sleep disturbed subjects during the second or third of three consecutive nights disturbed by heavy traffic noise. Prior drug administration reduced the noise induced disturbance of sleep stage patterns: slow-wave sleep and stage REM increased. It is recommended that the initial treatment of severe insomnia by "strong" sleeping pills should be followed by a period during which "weak" sleeping pills are given before the drug administration finally is discontinued.
将缬草和啤酒花的复方制剂Seda-Kneipp，在连续三个因交通噪音严重干扰睡眠的夜晚中的第二个或第三个晚上，给予睡眠受干扰的受试者。给药前可减少噪音引起的睡眠阶段模式紊乱：慢波睡眠和快速眼动睡眠阶段增加。建议在先用“强效”安眠药对严重失眠进行初始治疗后，应接着有一个阶段给予“弱效”安眠药，最后再停药。
