Schulz H, Stolz C, Müller J
AFB-PAREXEL Arzneimittelforschung GmbH, Berlin.
Pharmacopsychiatry. 1994 Jul;27(4):147-51. doi: 10.1055/s-2007-1014295.
The effect of acute and repeated treatment (seven days) with a valerian extract (Valdispert forte, 405 mg t.i.d.) on objective and subjective measures of sleep was studied. Polysomnography was conducted in 14 elderly poor sleepers on three nights, at one-week intervals (N0, N1, N2). N0 was an adaptation night, N1 and N2 the first and last night under treatment. Six subjects received placebo and eight subjects valerian. Subjects in the valerian group showed an increase in slow-wave sleep (SWS) and a decrease in sleep stage 1. Density of K-complexes was increased under active treatment. There was no effect on sleep onset time or time awake after sleep onset. REM sleep was unaltered. There was also no effect on self-rated sleep quality. We hypothesize that valerian increases SWS in subjects with low baseline values.
研究了缬草提取物（Valdispert forte，405毫克，每日三次）急性和重复治疗（七天）对睡眠客观和主观指标的影响。对14名老年睡眠不佳者进行了多导睡眠图检查，间隔一周进行三个晚上的检查（N0、N1、N2）。N0为适应夜，N1和N2为治疗的第一晚和最后一晚。6名受试者接受安慰剂，8名受试者接受缬草治疗。缬草组受试者的慢波睡眠（SWS）增加，睡眠1期减少。积极治疗下K复合波密度增加。对入睡时间或入睡后清醒时间没有影响。快速眼动睡眠未改变。对自评睡眠质量也没有影响。我们假设缬草会增加基线值较低的受试者的慢波睡眠。
