Diallo D A, Cissoko Ls, Cissoko Y, Diallo Y, Baby M, Mouhaha J, Diop Ct, Dembélé M, Sidibé At, Ndjinga Ndjinga V, Salissou Gm, Dicko Ms, Traoré Ha
Mali Med. 2005;20(4):1-3.
Summary This is a retrospective study on epidemiologic aspects of hematological malignancies from 1996 to 2003 in the Hospital of Point G, Bamako, Mali, in which we looked at files of all patients who visited the center during that period. During the study, 264 cases were diagnosed for hematological malignancies corresponding to an annual mean of 33 cases. Hematological malignancies were mostly lymphoid types (76.51%), among which NHL were predominant. For non lymphoid malignancies, CML was the most frequent (70.96 %). The prevalence of hematological malignancies was multiplied by 2.18 for lymphomas, 2.16 for leukemia, and 1.87 for multiple myeloma; whereas it was stable for other cases. The sex ratio was in favor of men with regard to all hematological malignancies except for CML that is more frequent un female (p=0,002). The case frequency repartition according to age showed a bimodal distribution with one peak for the 10-19 years old and another peak for the 40-49 years old. Among 44 patients tested for HIV, 11.4 % were positive. We couldn't establish a relationship with other classic risk factors. There were some particularities in the distribution of cases with regard to patient's provenances and the time spent before the hospital visits. The hospital-based mortality rate was 10.4 per 1000 and, lethality was high, probably because of case management difficulties and particular popular representation of the disease. More prospective studies with emphasis on risk factors in relation with hematological malignancies in Mali will help to better understand these observed epidemiologic particularities and to elaborate prevention and treatment strategies.
摘要 这是一项针对1996年至2003年期间马里巴马科G点医院血液系统恶性肿瘤流行病学方面的回顾性研究，我们查阅了该时期内所有到该中心就诊患者的病历。研究期间，共诊断出264例血液系统恶性肿瘤病例，年均33例。血液系统恶性肿瘤大多为淋巴样类型（76.51%），其中非霍奇金淋巴瘤占主导。对于非淋巴样恶性肿瘤，慢性粒细胞白血病最为常见（70.96%）。淋巴瘤的血液系统恶性肿瘤患病率乘以2.18，白血病乘以2.16，多发性骨髓瘤乘以1.87；而其他病例则保持稳定。除慢性粒细胞白血病在女性中更常见外（p = 0.002），所有血液系统恶性肿瘤的性别比均有利于男性。根据年龄的病例频率分布呈双峰分布，一个高峰在10 - 19岁，另一个高峰在40 - 49岁。在44例接受HIV检测的患者中，11.4%呈阳性。我们无法确定其与其他经典危险因素的关系。在病例分布方面，患者来源和就诊前的时间存在一些特殊性。基于医院的死亡率为每1000人中有10.4人，致死率较高，可能是由于病例管理困难以及该疾病在当地的特殊表现。更多侧重于马里血液系统恶性肿瘤相关危险因素的前瞻性研究将有助于更好地理解这些观察到的流行病学特殊性，并制定预防和治疗策略。
