Al-Osali Magdi E, Al-Qassabi Salim S, ElSayed Medhat K
Department of Internal Medicie, Bousher Polyclinic, Post Code 118, Muscat, Oman.
Saudi Med J. 2009 Jul;30(7):897-901.
To study serum total magnesium (Mg) levels in type 2 diabetic Omani patients, and to find the relation between Mg levels and glycosylated hemoglobin (HbA1c), body mass index (BMI), and age of the patient.
This work was carried out at the Bousher Polyclinic, Muscat, Oman from January to October 2008. We compared 34 type 2 diabetic patients with non-diabetic subjects as regards serum total Mg. We assessed diabetic patients in terms of age, gender, HbA1c, BMI, and their medications. Subjects at risk for apparent causes of hypomagnesemia or hypermagnesemia were excluded.
The mean serum total Mg level was 0.92 mmol/L (SD 0.06) in the control subjects, and 0.81 mmol/L (SD 0.08) in the diabetic group, and although almost all our diabetic patients have no hypomagnesemia, their levels of serum total Mg were significantly reduced compared with control subjects. T-test shows that our diabetics have significantly lower total Mg levels with a difference of 0.12 mmol/L (p=0.000) irrespective of age and gender. The Mg levels are positively correlated with age, but no correlation with HbA1c and BMI.
Although ionized and intracellular Mg levels are more reliable than total serum Mg in assessing Mg deficiency, low total serum levels of Mg are frequently seen in individuals with type 2 diabetes. Further studies on the role of Mg supplementation in the prevention of type 2 diabetes mellitus and its complications and similar studies in type 1 diabetes mellitus are recommended.
研究阿曼2型糖尿病患者的血清总镁（Mg）水平，并找出镁水平与糖化血红蛋白（HbA1c）、体重指数（BMI）及患者年龄之间的关系。
本研究于2008年1月至10月在阿曼马斯喀特的布舍尔综合诊所开展。我们比较了34例2型糖尿病患者与非糖尿病受试者的血清总镁水平。我们从年龄、性别、HbA1c、BMI及用药情况对糖尿病患者进行了评估。排除有明显低镁血症或高镁血症病因风险的受试者。
对照组受试者的血清总镁平均水平为0.92 mmol/L（标准差0.06），糖尿病组为0.81 mmol/L（标准差0.08），尽管几乎所有糖尿病患者均无低镁血症，但与对照组相比，他们的血清总镁水平显著降低。t检验显示，无论年龄和性别，我们的糖尿病患者总镁水平显著更低，差值为0.12 mmol/L（p = 0.000）。镁水平与年龄呈正相关，但与HbA1c和BMI无相关性。
尽管在评估镁缺乏时，离子化镁和细胞内镁水平比血清总镁更可靠，但2型糖尿病患者中经常可见血清总镁水平较低的情况。建议进一步研究补充镁在预防2型糖尿病及其并发症中的作用，以及在1型糖尿病中开展类似研究。
