Gerald Bronfman Center for Clinical Research in Oncology, McGill University, Montreal, Quebec H2W 1S6, Canada.
Support Care Cancer. 2009 Nov;17(11):1345-51. doi: 10.1007/s00520-009-0684-5. Epub 2009 Jul 18.
Malnutrition has been known to be associated with adverse outcomes in cancer patients. Patients who have been and/or are being treated for head and neck cancer have a compromised nutritional status. Nutritional deficits have a significant impact on mortality, morbidity, and quality of life.
The wasting in cancer cachexia involves loss of muscle and fat and reflects a catabolic metabolism induced by an abnormal host response to tumor presence and/or tumor factors. Disturbances of various physiological functions like taste, smell, dysphagia, xerostomia apart from cachexia can contribute to long-term nutritional complications and outcome.
Improved management of patients in posttreatment for head and neck cancer may require a multimodal approach by a multidisciplinary team and is best commenced earlier in the trajectory of the disease.
营养不良与癌症患者的不良预后相关。接受过和/或正在接受头颈部癌症治疗的患者其营养状况受损。营养不足对死亡率、发病率和生活质量有重大影响。
癌症恶病质中的消耗涉及肌肉和脂肪的损失,反映了宿主对肿瘤存在和/或肿瘤因素的异常反应引起的分解代谢。除恶病质外,味觉、嗅觉、吞咽困难、口干等各种生理功能的紊乱也会导致长期的营养并发症和后果。
改善头颈部癌症治疗后患者的管理可能需要多学科团队的多模式方法,最好在疾病进程的早期开始。