Departamento de Morfología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), 950 Sierra Mojada, Puerta 7, Edificio C, 1er Nivel, Guadalajara 44340, Jalisco, Mexico.
Cuerpo Académico UDG CA-874 "Ciencias Morfológicas en el Diagnóstico y Tratamiento de la Enfermedad", 950 Sierra Mojada, Puerta 7, Edificio C, 1er Nivel, Guadalajara 44340, Jalisco, Mexico.
Nutrients. 2022 Jul 24;14(15):3030. doi: 10.3390/nu14153030.
In patients with head and neck cancer, malnutrition is common. Most cases are treated by chemo-radiotherapy and surgery, with adverse effects on the aerodigestive area. Clinical and biochemical characteristics, health-related quality of life, survival, and risk of death were studied. The selected subjects were divided into normal- and low-phase-angle (PA) groups and followed up for at least two years. Mean ages were 67.2 and 59.3 years for low and normal PA, respectively. Patients with PA < 4.42° had significant differences in age, anthropometric and biochemical indicators of malnutrition, and inflammatory status compared to patients with PA > 4.42°. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. Median survival was 19.8 months for those with PA < 4.42° versus 34.4 months for those with PA > 4.42° (p < 0.001).The relative risk of death was related to low PA (2.6; p < 0.001). The percentage of living patients (41.7%) is almost the same as the percentage of deceased subjects (43.1%; p = 0.002), with high death rates in patients with PA < 4.42°. Phase angle was the most crucial predictor of survival and a risk factor for death in the studied cases.
在头颈部癌症患者中，营养不良很常见。大多数病例采用放化疗和手术治疗，对气消化道产生不良影响。本研究对临床和生化特征、健康相关生活质量、生存和死亡风险进行了研究。选择的受试者分为正常和低相位角（PA）组，并至少随访两年。低 PA 和正常 PA 组的平均年龄分别为 67.2 岁和 59.3 岁。PA<4.42°的患者在年龄、营养不良的人体测量和生化指标以及炎症状态方面与 PA>4.42°的患者有显著差异。在功能和症状量表方面存在统计学差异，低 PA 患者的功能评分较低，症状评分较高。PA<4.42°的患者中位生存期为 19.8 个月，PA>4.42°的患者为 34.4 个月（p<0.001）。死亡的相对风险与低 PA 相关（2.6；p<0.001）。存活患者（41.7%）的比例与死亡患者（43.1%）几乎相同（p=0.002），PA<4.42°的患者死亡率较高。相位角是研究病例中生存的最关键预测因素，也是死亡的危险因素。
