CoRPS-Center of Research on Psychology in Somatic diseases, Department of Medical Psychology, Tilburg University, P.O. Box 90153, 5000 LE, Tilburg, The Netherlands.
Qual Life Res. 2009 Oct;18(8):953-60. doi: 10.1007/s11136-009-9511-1. Epub 2009 Jul 19.
We examined the association between negative and positive affect and 12-month health status in patients treated with percutaneous coronary intervention (PCI) with drug-eluting stents.
Consecutive PCI patients (n = 562) completed the Global Mood Scale at baseline to assess affect and the EuroQoL-5D (EQ-5D) at baseline and 12-month follow-up to assess health status.
Negative affect [F(1, 522) = 17.14, P < .001] and positive affect [F(1, 522) = 5.11, P = .02] at baseline were independent associates of overall health status at 12-month follow-up, adjusting for demographic and clinical factors. Moreover, there was a significant interaction for negative by positive affect [F(1, 522) = 6.11, P = .01]. In domain-specific analyses, high negative affect was associated with problems in mobility, self-care, usual activities, pain/discomfort, and anxiety/depression with the risk being two to fivefold. Low positive affect was only associated with problems in self-care (OR: 8.14; 95% CI: 1.85-35.9; P = .006) and usual activities (OR: 1.87; 95% CI: 1.17-3.00; P = .009).
Baseline negative and positive affect contribute independently to patient-reported health status 12 months post PCI. Positive affect moderated the detrimental effects of negative affect on overall health status. Enhancing positive affect might be an important target to improve patient-centered outcomes in coronary artery disease.
我们研究了经皮冠状动脉介入治疗（PCI）置入药物洗脱支架后患者的负性和正性情绪与 12 个月健康状况之间的关系。
连续 PCI 患者（n=562）在基线时完成全球情绪量表以评估情绪，在基线和 12 个月随访时完成欧洲五维健康量表（EQ-5D）以评估健康状况。
基线时的负性情绪[F（1，522）=17.14，P<.001]和正性情绪[F（1，522）=5.11，P=0.02]是 12 个月随访时总体健康状况的独立预测因素，调整了人口统计学和临床因素。此外，负性情绪和正性情绪之间存在显著的交互作用[F（1，522）=6.11，P=0.01]。在特定领域的分析中，高负性情绪与移动、自我护理、日常活动、疼痛/不适和焦虑/抑郁问题相关，风险为两到五倍。低正性情绪仅与自我护理（OR：8.14；95%CI：1.85-35.9；P=0.006）和日常活动（OR：1.87；95%CI：1.17-3.00；P=0.009）相关。
基线时的负性和正性情绪独立预测 PCI 后 12 个月患者报告的健康状况。正性情绪调节了负性情绪对整体健康状况的不利影响。增强正性情绪可能是改善冠心病患者以患者为中心结局的重要目标。
