Kwan Marilyn L, Jensen Christopher D, Block Gladys, Hudes Mark L, Chu Lisa W, Buffler Patricia A
Kaiser Permanente, Division of Research, Oakland, CA 94612, USA.
Public Health Rep. 2009 Jul-Aug;124(4):503-14. doi: 10.1177/003335490912400407.
Intrauterine environmental factors, including maternal diet, may play an etiologic role in acute lymphoblastic leukemia (ALL), a common childhood cancer. Expanding on previous findings from phase 1 of the Northern California Childhood Leukemia Study (NCCLS), a population-based case-control study, we sought to further elucidate and replicate the relationships between maternal diet and ALL risk.
We matched 282 case-control sets of children (205 pairs and 77 triplets) from phases 1 and 2 of the NCCLS on sex, date of birth, mother's race, Hispanic racial/ethnic status, and county of residence at birth. We used an interviewer-administered food frequency questionnaire to obtain information on maternal dietary intake in the 12 months prior to pregnancy.
Risk of ALL was inversely associated with maternal consumption of vegetable (adjusted odds ratio [AOR] = 0.65, 95% confidence interval [CI] 0.50, 0.84); protein sources (AOR = 0.55, 95% CI 0.32, 0.96); fruit (AOR = 0.81, 95% CI 0.65, 1.00); and legume food groups (AOR = 0.75, 95% CI 0.59, 0.95). The risk reduction was strongest for consumption of the protein sources and vegetable food groups, independent of the child's diet up to age 2 years, and consistent across phases 1 and 2 of data collection for vegetable consumption.
These data suggest that it may be prudent for women to consume a diet rich in vegetables and adequate in protein prior to and during pregnancy as a possible means of reducing childhood ALL risk in their offspring.
子宫内环境因素，包括母亲的饮食，可能在急性淋巴细胞白血病（ALL）这一常见儿童癌症的病因中发挥作用。基于北加利福尼亚儿童白血病研究（NCCLS）第一阶段的前期研究结果（一项基于人群的病例对照研究），我们试图进一步阐明并重复母亲饮食与ALL风险之间的关系。
我们根据性别、出生日期、母亲的种族、西班牙裔种族/族裔身份以及出生时居住的县，对NCCLS第一阶段和第二阶段的282组儿童病例对照（205对和77组三胞胎）进行匹配。我们使用由访员管理的食物频率问卷来获取怀孕前12个月母亲饮食摄入的信息。
ALL风险与母亲食用蔬菜（调整后的优势比[AOR]=0.65，95%置信区间[CI]0.50，0.84）、蛋白质来源（AOR=0.55，95%CI0.32，0.96）、水果（AOR=0.81，95%CI0.65，1.00）和豆类食物组（AOR=0.75，95%CI0.59，0.95）呈负相关。蛋白质来源和蔬菜食物组的食用风险降低最为显著，与儿童2岁前的饮食无关，并且在蔬菜消费数据收集的第一阶段和第二阶段是一致的。
这些数据表明，女性在怀孕前和怀孕期间食用富含蔬菜且蛋白质充足的饮食可能是降低其后代儿童ALL风险的一种谨慎做法。
