The University of Western Australia, Telethon Institute for Child Health Research, Centre for Child Health Research, Perth, Australia.
Nutr Cancer. 2012;64(7):1122-30. doi: 10.1080/01635581.2012.707278. Epub 2012 Sep 11.
Our aim was to address the hypothesis that maternal dietary intake of folate during pregnancy is inversely associated with risk of acute lymphoblastic leukemia (ALL) in the offspring. Dietary intake of folate, vitamins B6 and B12 in the last 6 mo of pregnancy from 333 cases and 695 frequency-matched controls were assessed using a food frequency questionnaire. Data were analyzed using unconditional logistic regression, adjusting for study matching variables, total energy, and potentially confounding variables. Higher levels of dietary folate and B12 appeared to be associated with a decreased risk of ALL. Higher levels of vitamin B6 were associated with an increased risk. The strongest associations of ALL with these variables were seen when mothers consumed alcohol in pregnancy. Our findings are consistent with a modest protective effect of higher dietary intake of folate and vitamin B12 against ALL in the offspring, more particularly among women who drank alcohol during pregnancy. These findings are consistent with previous reports of the protective effects of a maternal diet high in fruit, vegetables, and nondairy protein sources. The vitamin B6 findings are not consistent with evidence that it is a protective factor against other cancers, and may be a chance finding.
我们的目的是验证这样一个假说，即孕妇在怀孕期间的叶酸饮食摄入量与后代急性淋巴细胞白血病（ALL）的风险呈负相关。通过食物频率问卷评估了 333 例病例和 695 例频率匹配对照者在妊娠最后 6 个月的叶酸、维生素 B6 和 B12 的饮食摄入量。使用非条件逻辑回归分析数据，调整了研究匹配变量、总能量和潜在混杂变量。较高的叶酸和 B12 饮食水平似乎与 ALL 风险降低有关。较高的维生素 B6 水平与风险增加有关。当母亲在怀孕期间饮酒时，这些变量与 ALL 的关联最强。我们的发现与较高的叶酸和维生素 B12 饮食摄入对后代 ALL 的适度保护作用一致，尤其是在怀孕期间饮酒的女性中。这些发现与之前关于富含水果、蔬菜和非乳制品蛋白质来源的母亲饮食对 ALL 的保护作用的报告一致。维生素 B6 的发现与它是其他癌症的保护因素的证据不一致，可能是偶然发现。
