Manzo Emiliano, Ciavatta M Letizia, Melck Dominique, Schupp Peter, de Voogd Nicole, Gavagnin Margherita
Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078-Pozzuoli (Naples), Italy.
J Nat Prod. 2009 Aug;72(8):1547-51. doi: 10.1021/np900310j.
Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.
从太平洋海绵共生体的主要成分——一种扁海绵属（Plakortis sp.）的样本中，分离出了六种未报道的芳香族化合物1-6，以及已知化合物脱氢姜黄酚和软海绵素。通过光谱方法对这些新分子进行了化学表征。化合物1-4含有一个六元环状过氧化物，而化合物5和6含有一个末端甲基酮。对这些新代谢产物进行了抗真菌和抗菌性能测试。化合物1和4对金黄色葡萄球菌有微弱活性。
