Rudi Amira, Afanii Rania, Gravalos Lola Garcia, Aknin Maurice, Gaydou Emile, Vacelet Jean, Kashman Yoel
School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel.
J Nat Prod. 2003 May;66(5):682-5. doi: 10.1021/np020589a.
In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH-EtOAc (1:1) extract of the sponge Plakortis aff simplex, collected in Madagascar, was found to be cytotoxic to a series of human tumor cells. From this sponge, three new compounds and one known one, two new 1,2-dioxane peroxylactones named plakortolides H (1) and I (2), and one new 1,2-dioxolane, designated andavadoic acid (3), have been isolated and their structures elucidated. In addition, the known N(3)-methyladenine (4) was isolated, to the best of our knowledge, for the first time from a marine source. Andavadoic acid (3) showed significant activity against 13 tumor cells with GI(50) values in the submicromolar range.
在我们持续开展的从海洋无脊椎动物中鉴定生物活性化合物的项目中，发现采自马达加斯加的海绵近似扁平扁海绵（Plakortis aff simplex）的甲醇 - 乙酸乙酯（1:1）提取物对一系列人类肿瘤细胞具有细胞毒性。从这种海绵中，分离出了三种新化合物和一种已知化合物，两种新的1,2 - 二氧六环过氧内酯，命名为扁海绵内酯H（1）和I（2），以及一种新的1,2 - 二氧戊环，命名为安达沃酸（3），并阐明了它们的结构。此外，据我们所知，首次从海洋来源分离出了已知的N(3)-甲基腺嘌呤（4）。安达沃酸（3）对13种肿瘤细胞显示出显著活性，其GI(50)值在亚微摩尔范围内。
