Ozkurt Bülent, Ozkurt Zübeyde Nur, Altay Murat, Aktekin Cem Nuri, Cağlayan Osman, Tabak Yalçin
Department of 5th Orthopedics and Traumatology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Eklem Hastalik Cerrahisi. 2009;20(2):78-84.
The aim of the present study was to evaluate the possible correlation between bone mass and serum adiponectin levels, and the correlation between adiponectin levels and osteoporotic fracture risk in a prospective clinical trial.
Postmenopausal non-diabetic 105 women (mean age 63.4+/-8.1; range 52 to 64 years) with hip fracture were evaluated. Of these 105 patients, 46 had trochanteric fractures, 24 had subtrochanteric fractures and 35 had femoral neck fractures. Anthropometric measurements were performed. Serum adiponectin level was measured by means of ELISA. Total bone mineral density and bone mineral content of lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry (DEXA).
Lumbar bone mineral density and proximal femoral bone mineral density were not correlated with serum adiponectin levels. Serum adiponectin level was not found to have any significant effect on bone mass. Serum adiponectin levels were not significantly different between the patients with osteoporotic fractures and those with non-osteoporotic fractures.
Our study showed that serum adiponectin level is not associated with bone mass and osteoporotic fracture risk. Investigation of local adiponectin levels in bony tissue is needed to clarify the possible relation between adiponectin and bone mass, and risk of fractures associated with osteoporosis.
本研究旨在通过一项前瞻性临床试验评估骨量与血清脂联素水平之间的可能相关性，以及脂联素水平与骨质疏松性骨折风险之间的相关性。
对105名绝经后非糖尿病髋部骨折女性（平均年龄63.4±8.1岁；年龄范围52至64岁）进行评估。在这105名患者中，46例为转子间骨折，24例为转子下骨折，35例为股骨颈骨折。进行人体测量。采用酶联免疫吸附测定法（ELISA）测量血清脂联素水平。通过双能X线吸收法（DEXA）测量腰椎和股骨近端的总骨密度和骨矿物质含量。
腰椎骨密度和股骨近端骨密度与血清脂联素水平无关。未发现血清脂联素水平对骨量有任何显著影响。骨质疏松性骨折患者与非骨质疏松性骨折患者的血清脂联素水平无显著差异。
我们的研究表明，血清脂联素水平与骨量和骨质疏松性骨折风险无关。需要对骨组织中的局部脂联素水平进行研究，以阐明脂联素与骨量之间的可能关系，以及与骨质疏松相关的骨折风险。
