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[2,6-二异丙基苯酚(丙泊酚)静脉灌注用于维持急诊麻醉]

[Intravenous perfusion of 2,6-diisopropylphenol (propofol) in the maintenance of emergency anesthesia].

作者信息

Miralles Pardo F S, Robles García E, Moreno Cuesta J, Iranzo Reverter J, Sánchez Ortega J L, López Rodríguez F

机构信息

Servicio de Anestesiología y Reanimación, Hospital Virgen de la Arrixaca, Murcia.

出版信息

Rev Esp Anestesiol Reanim. 1991 May-Jun;38(3):162-6.

PMID:1961960
Abstract

In the present study, we describe the use of 2,6 diisopropylphenol (propofol) in emergency surgery. Twenty ASA I and II patients underwent intravenous induction with thiopental (group I) and maintenance with a combination of oxygen/nitrous oxide (30/70%) and in other group of similar characteristics, propofol was used as single induction and maintenance hypnotic (group II). In both groups, atracurium besylate and fentanyl were used according to demand. In group II, there was a significant decrease in systolic blood pressure (16%; p less than 0.01) and diastolic blood pressure (12%; p less than 0.01) during induction as well as a lower incidence of side effects and a more progressive and rapid recovery (eye opening: group II = 16.3 +/- 3.3 minutes; group I = 39.7 +/- 6.3 minutes; p less than 0.01). On the basis of these findings, we believe propofol is a good alternative as single intravenous anesthetic for those patients undergoing emergency surgery and have no marked hemodynamic alterations.

摘要

在本研究中,我们描述了2,6 - 二异丙基苯酚(丙泊酚)在急诊手术中的应用。20例美国麻醉医师协会(ASA)分级为I级和II级的患者,一组(I组)采用硫喷妥钠静脉诱导,并用氧气/氧化亚氮(30/70%)混合气体维持麻醉;另一组特征相似的患者,采用丙泊酚作为单一诱导和维持麻醉的催眠药(II组)。两组均按需使用苯磺阿曲库铵和芬太尼。II组在诱导期间收缩压显著下降(16%;p < 0.01),舒张压显著下降(12%;p < 0.01),且副作用发生率较低,恢复过程更平稳、迅速(睁眼时间:II组 = 16.3 ± 3.3分钟;I组 = 39.7 ± 6.3分钟;p < 0.01)。基于这些发现,我们认为丙泊酚对于那些接受急诊手术且无明显血流动力学改变的患者而言,是一种很好的单一静脉麻醉替代药物。

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