Université de Franche-Comté, Besançon, France.
Peptides. 2009 Nov;30(11):2045-51. doi: 10.1016/j.peptides.2009.07.008. Epub 2009 Jul 18.
Numerous works associate the MCH peptide, and the hypothalamic neurons that produce it, to the feeding behavior and energy homeostasis. It is commonly admitted that MCH is an orexigenic peptide, and MCH neurons could be under the control of arcuate NPY and POMC neurons. However, the literature data is not always concordant. In particular questions about the intrahypothalamic circuit involving other neuropeptides and about the mechanisms through which MCH could act are not yet clearly answered. For example, which receptors mediate a MCH response to NPY or alpha-MSH, does MCH act alone, is there any local anatomical organization within the tuberal LHA? A review of the current literature is then needed to help focus attention on these unresolved and often neglected issues.
大量研究将 MCH 肽及其产生的下丘脑神经元与摄食行为和能量稳态联系起来。人们普遍认为 MCH 是一种食欲肽，MCH 神经元可能受弓状核 NPY 和 POMC 神经元的控制。然而，文献数据并不总是一致的。特别是关于涉及其他神经肽的下丘脑内回路以及 MCH 可能作用的机制的问题，尚未得到明确回答。例如，哪些受体介导 MCH 对 NPY 或 alpha-MSH 的反应，MCH 是否单独起作用，结节漏斗区（LHA）内是否存在任何局部解剖组织？因此，需要对当前文献进行综述，以帮助关注这些未解决且经常被忽视的问题。
