Université de Franche-Comté, Besançon, France.
Peptides. 2009 Nov;30(11):1969-72. doi: 10.1016/j.peptides.2009.07.016. Epub 2009 Aug 6.
Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide during development; second, in the rat, birth date greatly influence the phenotype of MCH neurons. At least two sub-populations were described on the basis of their chemical phenotype, projection pattern and birth date. The understanding of processes involved in the differentiation of these sub-populations may help understand the medio-lateral differentiation of the tuberal hypothalamus.
虽然有大量关于 MCH 神经元的研究，但很少有研究致力于研究它们的发育过程。然而，现有文献指出了两个重要特征：首先，这些神经元在迄今为止所有研究的物种中很早就分化出了 MCH 表型，这可能表明 MCH 肽在发育过程中起作用；其次，在大鼠中，出生日期极大地影响了 MCH 神经元的表型。至少有两个亚群是根据其化学表型、投射模式和出生日期来描述的。了解这些亚群分化过程中涉及的机制可能有助于理解结节下丘脑的中侧分化。
