[不同临床阶段的HIV/AIDS患者胃黏膜中的幽门螺杆菌感染]

[Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages].

作者信息

Luo Hong-Bin, Hu Zhong-Wei, Guo Jia-Wei

机构信息

Department of Gastroenterology, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29(7):1397-9.

PMID:19620064

Abstract

OBJECTIVE

To analyze Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages.

METHODS

This study involved 170 patients with HIV/AIDS and 34 HIV-negative patients. All the patients underwent upper endoscopy and antral gastric biopsy to determine the status of Helicobacter pylori infection using aniline red staining and rapid urease test. The patients with HIV/AIDS were stratified based on CD4(+)T lymphocyte counts and clinical setting into asymptomatic HIV infection (A1, A2) group, symptomatic HIV infection (B1, B2) group and AIDS (A3, B3, C1-3) group.

RESULTS

The prevalence of Helicobacter pylori infection in HIV/AIDS patients was 16.5% (28/170), and in the 3 groups classified, the infection rates were 23.4% (11/47), 14.0% (8/57), and 13.6% (9/66), respectively; the infection rate was 47.1% (16/34) in the control group. Helicobacter pylori infection rate in the gastric mucosa of the patients with HIV/AIDS in different clinical stages was significantly lower than that of the control group (P<0.05); the infection rates in symptomatic HIV-infected (B1, B2) group and AIDS (A3, B3, C1-3) group were significantly lower than that in asymptomatic HIV-infected (A1, A2) group (P<0.05).

CONCLUSION

The low Helicobacter pylori infection rate in HIV/AIDS patients may result from severe immunodeficiency in the gastric mucosa.

摘要

目的

分析不同临床阶段的HIV/AIDS患者胃黏膜中的幽门螺杆菌感染情况。

方法

本研究纳入了170例HIV/AIDS患者和34例HIV阴性患者。所有患者均接受上消化道内镜检查及胃窦活检，采用苯胺红染色和快速尿素酶试验确定幽门螺杆菌感染状况。根据CD4(+)T淋巴细胞计数和临床情况，将HIV/AIDS患者分为无症状HIV感染（A1、A2）组、有症状HIV感染（B1、B2）组和AIDS（A3、B3、C1 - 3）组。

结果

HIV/AIDS患者中幽门螺杆菌感染率为16.5%（28/170），在分类的3组中，感染率分别为23.4%（11/47）、14.0%（8/57）和13.6%（9/66）；对照组感染率为47.1%（16/34）。不同临床阶段的HIV/AIDS患者胃黏膜中幽门螺杆菌感染率显著低于对照组（P<0.05）；有症状HIV感染（B1、B2）组和AIDS（A3、B3、C1 - 3）组的感染率显著低于无症状HIV感染（A1、A2）组（P<0.05）。