Battan R, Raviglione M C, Palagiano A, Boyle J F, Sabatini M T, Sayad K, Ottaviano L J
Department of Medicine, Cabrini Medical Center, New York City, New York.
Am J Gastroenterol. 1990 Dec;85(12):1576-9.
A controlled study was conducted on patients with human immunodeficiency virus (HIV) infection referred for upper endoscopy to evaluate the prevalence of Helicobacter pylori (H. pylori) infection. Four different stains and culture for H. pylori were performed on biopsy specimens from the gastric antrum. Sixteen (40%) of 40 patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) were diagnosed to be infected with H. pylori versus 14 (39%) of 36 age-matched control patients. Eight of 15 AIDS/ARC patients without AIDS-related esophagogastroduodenal findings (53%) were infected with H. pylori versus 8/25 (32%) with endoscopic findings typical of AIDS. No invasion of the lamina propria by H. pylori was noted in any patient. Active chronic gastritis was present in 60% of AIDS/ARC patients and 61% of controls. Fifty-eight and 59%, respectively, of active chronic gastritis cases were infected with H. pylori. All the H. pylori infections, except one, were found in patients with chronic gastritis. In AIDS/ARC patients, H. pylori infection and active chronic gastritis are as common as in other patients referred for upper endoscopy. They may play a pathogenic role, especially when endoscopic AIDS-related findings are lacking. Cell-mediated immune deficiency does not appear to increase the risk of infection with H. pylori.
对因上消化道内镜检查而转诊的人类免疫缺陷病毒（HIV）感染患者进行了一项对照研究，以评估幽门螺杆菌（H. pylori）感染的患病率。对胃窦活检标本进行了四种不同的幽门螺杆菌染色和培养。40例获得性免疫缺陷综合征（AIDS）或AIDS相关综合征（ARC）患者中有16例（40%）被诊断为幽门螺杆菌感染，而36例年龄匹配的对照患者中有14例（39%）。15例无AIDS相关食管胃十二指肠病变的AIDS/ARC患者中有8例（53%）感染幽门螺杆菌，而25例有典型AIDS内镜表现的患者中有8例（32%）感染。在任何患者中均未发现幽门螺杆菌侵犯固有层。60%的AIDS/ARC患者和61%的对照患者存在活动性慢性胃炎。活动性慢性胃炎病例中分别有58%和59%感染了幽门螺杆菌。除1例患者外，所有幽门螺杆菌感染均见于慢性胃炎患者。在AIDS/ARC患者中，幽门螺杆菌感染和活动性慢性胃炎与因上消化道内镜检查而转诊的其他患者一样常见。它们可能起致病作用，尤其是在缺乏与AIDS相关的内镜表现时。细胞介导的免疫缺陷似乎不会增加幽门螺杆菌感染的风险。
