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听觉言语幻觉的现实性。

Reality of auditory verbal hallucinations.

机构信息

Brain Research Unit, Low Temperature Laboratory and Advanced Magnetic Imaging Centre, Helsinki University of Technology, Espoo, Finland.

出版信息

Brain. 2009 Nov;132(Pt 11):2994-3001. doi: 10.1093/brain/awp186. Epub 2009 Jul 20.

DOI:10.1093/brain/awp186
PMID:19620178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2768657/
Abstract

Distortion of the sense of reality, actualized in delusions and hallucinations, is the key feature of psychosis but the underlying neuronal correlates remain largely unknown. We studied 11 highly functioning subjects with schizophrenia or schizoaffective disorder while they rated the reality of auditory verbal hallucinations (AVH) during functional magnetic resonance imaging (fMRI). The subjective reality of AVH correlated strongly and specifically with the hallucination-related activation strength of the inferior frontal gyri (IFG), including the Broca's language region. Furthermore, how real the hallucination that subjects experienced was depended on the hallucination-related coupling between the IFG, the ventral striatum, the auditory cortex, the right posterior temporal lobe, and the cingulate cortex. Our findings suggest that the subjective reality of AVH is related to motor mechanisms of speech comprehension, with contributions from sensory and salience-detection-related brain regions as well as circuitries related to self-monitoring and the experience of agency.

摘要

现实感的扭曲，表现在妄想和幻觉中，是精神病的关键特征，但潜在的神经元相关性在很大程度上仍是未知的。我们研究了 11 名功能高度正常的精神分裂症或分裂情感障碍患者，让他们在功能磁共振成像（fMRI）期间对听觉言语幻觉（AVH）的现实感进行评分。AVH 的主观现实性与下额前回（IFG）的幻觉相关激活强度强烈且特异性相关，包括布罗卡语言区。此外，受试者所经历的幻觉有多真实取决于 IFG、腹侧纹状体、听觉皮层、右颞叶后区和扣带回皮层之间与幻觉相关的耦合。我们的发现表明，AVH 的主观现实性与言语理解的运动机制有关，涉及到感觉和显著性检测相关的脑区以及与自我监控和代理体验相关的回路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/821ed26319a3/awp186f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/2677361a1c69/awp186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/81336e1692fa/awp186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/cddf79dec2f5/awp186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/821ed26319a3/awp186f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/2677361a1c69/awp186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/81336e1692fa/awp186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/cddf79dec2f5/awp186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4868/2768657/821ed26319a3/awp186f4.jpg

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Brain. 2008 Dec;131(Pt 12):3169-77. doi: 10.1093/brain/awn251. Epub 2008 Oct 13.
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Deficit in a neural correlate of reality monitoring in schizophrenia patients.精神分裂症患者现实监测的神经关联缺陷。
Schizophr Bull. 2024 Nov 8;50(6):1326-1336. doi: 10.1093/schbul/sbae020.
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Structural aging of human neurons is opposite of the changes in schizophrenia.人类神经元的结构老化与精神分裂症的变化相反。
PLoS One. 2023 Jun 23;18(6):e0287646. doi: 10.1371/journal.pone.0287646. eCollection 2023.
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Diagnosis of Schizophrenia Based on the Data of Various Modalities: Biomarkers and Machine Learning Techniques (Review).基于多种模态数据的精神分裂症诊断：生物标志物和机器学习技术（综述）。
Sovrem Tekhnologii Med. 2022;14(5):53-75. doi: 10.17691/stm2022.14.5.06. Epub 2022 Sep 29.
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Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations.精神分裂症患者有无幻听时言语感知的大脑相关性研究。
PLoS One. 2022 Dec 16;17(12):e0276975. doi: 10.1371/journal.pone.0276975. eCollection 2022.
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