在体外药效学模型中，用大肠杆菌结合达托霉素、利奈唑胺或万古霉素评估氨曲南和头孢他啶的药效学。
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.
作者信息
LaPlante Kerry L, Sakoulas George
机构信息
Department of Pharmacy Practice, University of Rhode Island, Kingston, Rhode Island, USA.
出版信息
Antimicrob Agents Chemother. 2009 Oct;53(10):4549-55. doi: 10.1128/AAC.00180-09. Epub 2009 Jul 20.
Abstract
In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.
摘要
在体外药效学模型中，利奈唑胺减弱了氨曲南和头孢他啶对大肠杆菌的活性。相反，当将达托霉素或万古霉素添加到氨曲南和头孢他啶中时，在24小时和48小时检测到协同作用。我们得出结论，革兰氏阳性谱和革兰氏阴性谱抗菌药物之间可能会发生显著但未得到充分认识的相互作用。
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