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1
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.在体外药效学模型中，用大肠杆菌结合达托霉素、利奈唑胺或万古霉素评估氨曲南和头孢他啶的药效学。
Antimicrob Agents Chemother. 2009 Oct;53(10):4549-55. doi: 10.1128/AAC.00180-09. Epub 2009 Jul 20.
2
Activity of daptomycin or linezolid in combination with rifampin or gentamicin against biofilm-forming Enterococcus faecalis or E. faecium in an in vitro pharmacodynamic model using simulated endocardial vegetations and an in vivo survival assay using Galleria mellonella larvae.在使用模拟心内膜赘生物的体外药效学模型以及使用大蜡螟幼虫的体内存活试验中，达托霉素或利奈唑胺与利福平或庆大霉素联合使用对形成生物膜的粪肠球菌或屎肠球菌的活性。
Antimicrob Agents Chemother. 2014 Aug;58(8):4612-20. doi: 10.1128/AAC.02790-13. Epub 2014 May 27.
3
Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.评估标准剂量和高剂量达托霉素与利奈唑胺对模拟心内膜赘生物的体外药代动力学/药效学模型中万古霉素耐药肠球菌分离株的作用。
Antimicrob Agents Chemother. 2012 Jun;56(6):3174-80. doi: 10.1128/AAC.06439-11. Epub 2012 Apr 2.
4
Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vitro pharmacodynamic models.克林霉素、达托霉素、多西环素、利奈唑胺、甲氧苄啶-磺胺甲恶唑和万古霉素在小鼠大腿感染及体外药效学模型中对具有诱导型克林霉素耐药性的社区获得性耐甲氧西林金黄色葡萄球菌的活性。
Antimicrob Agents Chemother. 2008 Jun;52(6):2156-62. doi: 10.1128/AAC.01046-07. Epub 2008 Apr 14.
5
Linezolid and vancomycin, alone and in combination with rifampin, compared with moxifloxacin against a multidrug-resistant and a vancomycin-tolerant Streptococcus pneumoniae strain in an in vitro pharmacodynamic model.在体外药效学模型中，将利奈唑胺和万古霉素单独及与利福平联合使用，与莫西沙星相比，用于对抗一株耐多药和耐万古霉素的肺炎链球菌菌株。
Antimicrob Agents Chemother. 2003 Jun;47(6):1984-7. doi: 10.1128/AAC.47.6.1984-1987.2003.
6
In vitro synergy of daptomycin plus rifampin against Enterococcus faecium resistant to both linezolid and vancomycin.达托霉素联合利福平对耐利奈唑胺和万古霉素的屎肠球菌的体外协同作用
Antimicrob Agents Chemother. 2005 Dec;49(12):5166-8. doi: 10.1128/AAC.49.12.5166-5168.2005.
7
Bactericidal activities of daptomycin, quinupristin-dalfopristin, and linezolid against vancomycin-resistant Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetations.在具有模拟心内膜赘生物的体外药效学模型中，达托霉素、奎奴普丁-达福普汀和利奈唑胺对耐万古霉素金黄色葡萄球菌的杀菌活性。
Antimicrob Agents Chemother. 2003 Dec;47(12):3960-3. doi: 10.1128/AAC.47.12.3960-3963.2003.
8
Impact of Enterococcus faecalis on the bactericidal activities of arbekacin, daptomycin, linezolid, and tigecycline against methicillin-resistant Staphylococcus aureus in a mixed-pathogen pharmacodynamic model.粪肠球菌对阿贝卡星、达托霉素、利奈唑胺和替加环素在混合病原体药效学模型中针对耐甲氧西林金黄色葡萄球菌的杀菌活性的影响。
Antimicrob Agents Chemother. 2006 Apr;50(4):1298-303. doi: 10.1128/AAC.50.4.1298-1303.2006.
9
Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model.在体外药效学模型中，高接种量金黄色葡萄球菌对萘夫西林、万古霉素、利奈唑胺和达托霉素单独及与庆大霉素联合使用时活性的影响。
Antimicrob Agents Chemother. 2004 Dec;48(12):4665-72. doi: 10.1128/AAC.48.12.4665-4672.2004.
10
Activity of linezolid and daptomycin against methicillin-resistant coagulase-negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients.利奈唑胺和达托霉素对从儿科患者血培养中分离出的对万古霉素MIC升高的耐甲氧西林凝固酶阴性葡萄球菌的活性。
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Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria.消除细胞外三磷酸腺苷用于快速预测针对耐碳青霉烯类革兰氏阴性菌的24小时时间杀菌研究中的定量菌落计数
Microorganisms. 2020 Sep 28;8(10):1489. doi: 10.3390/microorganisms8101489.
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Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence.六小时内使用 ATP 生物发光技术快速检测耐碳青霉烯类革兰氏阴性菌的抗生素联合
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3
Combination of Tedizolid and Daptomycin against Methicillin-Resistant Staphylococcus aureus in an Model of Simulated Endocardial Vegetations.替加环素与达托霉素联合应用于模拟心内膜赘生物的耐甲氧西林金黄色葡萄球菌感染模型
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4
Busting the Myth of "Static vs Cidal": A Systemic Literature Review.打破“静态与杀菌”的神话：系统文献综述。
Clin Infect Dis. 2018 Apr 17;66(9):1470-1474. doi: 10.1093/cid/cix1127.
5
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Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01509-16. Print 2017 Jan.
6
From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB).从实验台到病床旁：一项前瞻性体外抗生素联合检测（iACT）服务，以指导针对广泛耐药（XDR）革兰氏阴性菌（GNB）合理优化抗菌药物组合的选择。
PLoS One. 2016 Jul 21;11(7):e0158740. doi: 10.1371/journal.pone.0158740. eCollection 2016.
7
Pairwise antibiotic interactions in Escherichia coli: triclosan, rifampicin and aztreonam with nine other classes of antibiotics.大肠杆菌中的抗生素两两相互作用：三氯生、利福平、氨曲南与其他九类抗生素的相互作用
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8
Ampicillin in Combination with Ceftaroline, Cefepime, or Ceftriaxone Demonstrates Equivalent Activities in a High-Inoculum Enterococcus faecalis Infection Model.氨苄西林与头孢洛林、头孢吡肟或头孢曲松联合使用在高接种量粪肠球菌感染模型中显示出同等活性。
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3178-82. doi: 10.1128/AAC.03126-15. Print 2016 May.
9
Observed Antagonistic Effect of Linezolid on Daptomycin or Vancomycin Activity against Biofilm-Forming Methicillin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model.在体外药效学模型中观察到利奈唑胺对达托霉素或万古霉素抗生物膜形成耐甲氧西林金黄色葡萄球菌活性的拮抗作用。
Antimicrob Agents Chemother. 2015 Dec;59(12):7790-4. doi: 10.1128/AAC.01604-15. Epub 2015 Sep 14.
10
A propensity score analysis shows that empirical treatment with linezolid does not increase the thirty-day mortality rate in patients with Gram-negative bacteremia.一项倾向评分分析表明，利奈唑胺经验性治疗不会增加革兰氏阴性菌血症患者的30天死亡率。
Antimicrob Agents Chemother. 2014 Dec;58(12):7025-31. doi: 10.1128/AAC.03796-14. Epub 2014 Sep 8.

本文引用的文献

1
Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study.复杂性皮肤和皮肤结构感染以及导管相关血流感染：利奈唑胺在一项3期研究中的非劣效性
Clin Infect Dis. 2009 Jan 15;48(2):203-12. doi: 10.1086/595686.
2
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.恶唑烷酮类抗生素会干扰核糖体肽基转移酶中心并影响tRNA定位。
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13339-44. doi: 10.1073/pnas.0804276105. Epub 2008 Aug 29.
3
Development and validation of an agar diffusion assay for determination of ceftazidime in pharmaceutical preparations.用于测定药物制剂中头孢他啶的琼脂扩散法的建立与验证
J AOAC Int. 2008 Jan-Feb;91(1):59-66.
4
Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation.氨曲南在健康受试者和囊性纤维化患者中的药代动力学以及使用蒙特卡洛模拟评估剂量-暴露关系
Antimicrob Agents Chemother. 2007 Sep;51(9):3049-55. doi: 10.1128/AAC.01522-06. Epub 2007 Jun 18.
5
Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation.利奈唑胺在大肠杆菌、弗氏柠檬酸杆菌和产气肠杆菌中的细胞内蓄积：增强的外排泵活性和失活的作用。
J Antimicrob Chemother. 2007 Jun;59(6):1261-4. doi: 10.1093/jac/dkl380. Epub 2006 Sep 13.
6
Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones.恶唑烷酮类对哺乳动物线粒体蛋白质合成的抑制作用。
Antimicrob Agents Chemother. 2006 Jun;50(6):2042-9. doi: 10.1128/AAC.01411-05.
7
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.肺炎链球菌核糖体蛋白L4对恶唑烷酮类、大环内酯类和氯霉素耐药的新机制。
Antimicrob Agents Chemother. 2005 Aug;49(8):3554-7. doi: 10.1128/AAC.49.8.3554-3557.2005.
8
Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model.在体外药效学模型中，高接种量金黄色葡萄球菌对萘夫西林、万古霉素、利奈唑胺和达托霉素单独及与庆大霉素联合使用时活性的影响。
Antimicrob Agents Chemother. 2004 Dec;48(12):4665-72. doi: 10.1128/AAC.48.12.4665-4672.2004.
9
Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin; studies including observations on an apparent antagonism between penicillin and aureomycin.用青霉素与青霉素加金霉素治疗肺炎球菌性脑膜炎的比较研究；包括对青霉素与金霉素之间明显拮抗作用的观察。
AMA Arch Intern Med. 1951 Oct;88(4):489-94. doi: 10.1001/archinte.1951.03810100073006.
10
Studies on antibiotic synergism and antagonism; the interference of chloramphenicol with the action of penicillin.抗生素协同作用与拮抗作用的研究；氯霉素对青霉素作用的干扰。
AMA Arch Intern Med. 1951 Mar;87(3):349-59. doi: 10.1001/archinte.1951.03810030022002.

在体外药效学模型中，用大肠杆菌结合达托霉素、利奈唑胺或万古霉素评估氨曲南和头孢他啶的药效学。

Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.

作者信息

LaPlante Kerry L, Sakoulas George

机构信息

Department of Pharmacy Practice, University of Rhode Island, Kingston, Rhode Island, USA.

出版信息

Antimicrob Agents Chemother. 2009 Oct;53(10):4549-55. doi: 10.1128/AAC.00180-09. Epub 2009 Jul 20.

DOI:10.1128/AAC.00180-09
PMID:19620335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2764192/
Abstract

In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.

摘要

在体外药效学模型中，利奈唑胺减弱了氨曲南和头孢他啶对大肠杆菌的活性。相反，当将达托霉素或万古霉素添加到氨曲南和头孢他啶中时，在24小时和48小时检测到协同作用。我们得出结论，革兰氏阳性谱和革兰氏阴性谱抗菌药物之间可能会发生显著但未得到充分认识的相互作用。