基因组扩增子靶向乳腺癌中的囊泡循环。
Genomic amplicons target vesicle recycling in breast cancer.
作者信息
Mills Gordon B, Jurisica Igor, Yarden Yosef, Norman Jim C
机构信息
Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
J Clin Invest. 2009 Aug;119(8):2123-7. doi: 10.1172/JCI40256. Epub 2009 Jul 20.
Abstract
Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.
摘要
异常的内吞作用、囊泡靶向运输和受体循环是癌症新出现的特征。在本期《临床研究杂志》中，张及其同事证明，RAB偶联蛋白（RCP；也称为RAB11FIP1）在人类乳腺癌和小鼠乳腺癌异种移植模型中是8p11 - 12扩增子的“驱动因素”（见第2171页开始的相关文章）。他们发现RAB GTPase功能可使基因组扩增赋予乳腺肿瘤侵袭性，这大大增加了支持受体运输在癌症增殖和转移中起关键作用的证据。
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本文引用的文献
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The emerging role of the RAB25 small GTPase in cancer.RAB25 小分子 GTP 酶在癌症中的新兴作用。
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RCP is a human breast cancer-promoting gene with Ras-activating function.RCP是一种具有Ras激活功能的人类乳腺癌促进基因。
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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.高尔基体蛋白3（GOLPH3）调节癌症中的mTOR信号传导和雷帕霉素敏感性。
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Derailed endocytosis: an emerging feature of cancer.内吞作用失调：癌症的一个新特征。
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Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.Rab 偶联蛋白协调α5β1整合素和表皮生长因子受体1的再循环，以促进细胞在三维微环境中的迁移。
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Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.整合基因组学确定RAB23为弥漫型胃癌中的侵袭介导基因。
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Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.磷脂酰肌醇3激酶p85亚基的RabGAP功能紊乱导致细胞转化。
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