Mills Gordon B, Jurisica Igor, Yarden Yosef, Norman Jim C
Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
J Clin Invest. 2009 Aug;119(8):2123-7. doi: 10.1172/JCI40256. Epub 2009 Jul 20.
Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.
异常的内吞作用、囊泡靶向运输和受体循环是癌症新出现的特征。在本期《临床研究杂志》中，张及其同事证明，RAB偶联蛋白（RCP；也称为RAB11FIP1）在人类乳腺癌和小鼠乳腺癌异种移植模型中是8p11 - 12扩增子的“驱动因素”（见第2171页开始的相关文章）。他们发现RAB GTPase功能可使基因组扩增赋予乳腺肿瘤侵袭性，这大大增加了支持受体运输在癌症增殖和转移中起关键作用的证据。
