Fujisaki Y, Miura Y, Sugimori T, Morimoto T, Ino T
Natl Inst Anim Health Q (Tokyo). 1977 Summer;17(2):39-44.
Studies were made on the effect of the route of inoculation on the establishment of experimental vertical infection of mice with Japanese encephalitis virus. Mice of the three strains, CFW, C3H/He, and C57BL/6, were inoculated with a field strain of the virus by the intravenous, intraperitoneal, or subcutaneous route. An attempt was made on them to recover the virus from the placenta and fetus. As a result, there were differences in rate of plancental and fetal infection among the route of inoculation. It was dependent the establishment of vertical infection. In general, the rates of placental and fetal infection were the highest in the case of intravenous inoculation, the second highest in the case of intraperitoneal inoculation, and the lowest in the case of subcutaneous inoculation, although there were small differences in this tendency among the mouse strains used. The differences in the rates of placental and fetal infection were presumed to be derived not from the difference in the severity of infection of the respective mothers, but from the degree of direct approach of virus to the placenta as one of the factors.
研究了接种途径对小鼠实验性垂直感染日本脑炎病毒的影响。将CFW、C3H/He和C57BL/6这三种品系的小鼠通过静脉、腹腔或皮下途径接种病毒的一个野毒株。尝试从它们的胎盘和胎儿中分离病毒。结果，接种途径之间胎盘和胎儿感染率存在差异。这取决于垂直感染的建立。一般来说，静脉接种时胎盘和胎儿感染率最高，腹腔接种其次，皮下接种最低，尽管所用小鼠品系之间在这种趋势上存在细微差异。胎盘和胎儿感染率的差异推测不是源于各母体感染严重程度的差异，而是源于病毒作为因素之一直接接触胎盘的程度。
