Miura K, Goto N, Suzuki H, Fujisaki Y
National Institute of Animal Health, Ibaraki, Japan.
Jikken Dobutsu. 1988 Oct;37(4):365-73. doi: 10.1538/expanim1978.37.4_365.
Eight strains of mice were examined for their susceptibilities to intraperitoneal infection with AS-6 strain of Japanese encephalitis virus (JEV). 1) C3H/He mice suffered from a high mortality as well as infection rate. 2) C57BL/6, RR, NC and KK mice showed approximately the same infection rates as C3H/He, while these strains showed significantly lower mortalities than C3H/He. 3) AA, BALB/c and ddY mice showed no death and had the lowest infection rates among the eight strains. There was no difference in the virus recovery from six visceral organs (except the brain) between C3H/He, C57BL/6 and AA. Despite the equal degree of preceding viremia, the incidence of encephalitis was much lower in C57BL/6 than in C3H/He. The same strain difference as the above was also observed in C3H/He and C57BL/6 by intravenous inoculation with JEV. However, there was no difference in mortality between C3H/He and C57BL/6 mice when intracerebrally inoculated with JEV. The incubation period and survival time in the intracerebral inoculation were shorter than in the intraperitoneal and intravenous inoculations. The three types of strains were characterized: the first (C3H/He) was highly susceptible to both visceral phase infection (VI) and nervous phase infection (NI): the second (C57BL/6) was susceptible to VI but resistant to NI, and the third (AA) was probably resistant to VI and highly resistant to NI.
检测了八品系小鼠对日本脑炎病毒（JEV）AS - 6株腹腔感染的易感性。1）C3H/He小鼠死亡率和感染率都很高。2）C57BL/6、RR、NC和KK小鼠的感染率与C3H/He大致相同，而这些品系的死亡率显著低于C3H/He。3）AA、BALB/c和ddY小鼠无死亡，且在八品系中感染率最低。C3H/He、C57BL/6和AA在六个内脏器官（除脑外）的病毒回收率无差异。尽管病毒血症前期程度相同，但C57BL/6的脑炎发病率远低于C3H/He。通过静脉接种JEV，在C3H/He和C57BL/6中也观察到了上述相同的品系差异。然而，脑内接种JEV时，C3H/He和C57BL/6小鼠死亡率无差异。脑内接种的潜伏期和存活时间比腹腔接种和静脉接种短。三种品系的特点如下：第一种（C3H/He）对内脏期感染（VI）和神经期感染（NI）均高度易感；第二种（C57BL/6）对VI易感但对NI有抗性；第三种（AA）可能对VI有抗性且对NI高度抗性。
