蛋白激酶对 Wnt/β-连环蛋白信号通路的调控。
Regulation of Wnt/beta-catenin signaling by protein kinases.
机构信息
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
出版信息
Dev Dyn. 2010 Jan;239(1):34-44. doi: 10.1002/dvdy.22019.
Abstract
The Wnt/beta-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.
摘要
Wnt/β-catenin 信号通路在发育和成人组织稳态中发挥着重要作用。该通路的异常激活可导致多种恶性肿瘤的发生。蛋白激酶已成为 Wnt 通路多个步骤的关键调节因子。在这篇综述中，我们综合了最新信息，介绍了不同蛋白激酶如何调节 Wnt 信号转导。
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