地夫可特长期治疗可减少mdx小鼠的心肌纤维化。
Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice.
作者信息
Marques Maria Julia, Oggiam Daniella Silva, Barbin Isabel Cristina Chagas, Ferretti Renato, Santo Neto Humberto
机构信息
Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970, Campinas, SP, Brazil.
出版信息
Muscle Nerve. 2009 Sep;40(3):466-8. doi: 10.1002/mus.21341.
We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.
我们评估了长期给予地夫可特（DFZ）对mdx小鼠心肌纤维化进展的影响。对6月龄的mdx小鼠给予DFZ治疗15个月。通过组织形态计量学方法评估心肌纤维化（MF），并比较相同年龄（21月龄）接受治疗和未接受治疗的mdx小鼠。DFZ显著降低了MF。我们得出结论，长期使用DFZ治疗可有效减缓肌营养不良蛋白缺乏心脏中纤维化的进展。
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