Kim Sollip, Min Won-Ki, Chun Sail, Lee Woochang, Chung Hee-Jung, Lee Pil Ryang, Kim Ahm
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea.
J Clin Lab Anal. 2009;23(4):231-6. doi: 10.1002/jcla.20326.
We devised a complementary quantitative method for gestational diabetes (GDM) that uses the area under the curve (AUC) of the results of the oral glucose tolerance test (OGTT), and evaluated its efficacy in predicting neonates that would be large for gestational age (LGA). The study subjects were 648 pregnant women. The AUC-OGTT (concentration x time) was calculated from the 100-g OGTT results. The incidence of LGA according to each range of the AUC-OGTT was estimated and odds ratios were analyzed using multiple logistic regression analysis.The incidence of LGA increased with the AUC-OGTT value and was 0% for AUC<300, 7.8% for 300-400, 14.9% for 400-500, 20.8% for 500-600, and 45.5% for > or = 600. The odds ratio of LGA increased by approximately two-fold with an increase of 100 in the AUC-OGTT. The results indicated that the AUC-OGTT can be used to quantify the risk of LGA in GDM. The AUC-OGTT could complement a diagnosis of GDM using conventional diagnostic criteria.
我们设计了一种用于妊娠期糖尿病（GDM）的补充定量方法，该方法使用口服葡萄糖耐量试验（OGTT）结果的曲线下面积（AUC），并评估其在预测大于胎龄儿（LGA）方面的有效性。研究对象为648名孕妇。根据100克OGTT结果计算AUC-OGTT（浓度×时间）。估计AUC-OGTT各范围对应的LGA发生率，并使用多因素逻辑回归分析来分析比值比。LGA的发生率随AUC-OGTT值的增加而升高，AUC<300时为0%，300-400时为7.8%，400-500时为14.9%，500-600时为20.8%，≥600时为45.5%。AUC-OGTT每增加100，LGA的比值比增加约两倍。结果表明，AUC-OGTT可用于量化GDM中LGA的风险。AUC-OGTT可以补充使用传统诊断标准对GDM的诊断。
