Wan Na, Zhang Haiyan, Xu Runchun, Zheng Qin, Yang Ming
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(7):839-42.
To investigate the regulation of geniposide nasal absorption.
We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.
Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.
The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).
研究栀子苷鼻腔吸收的规律。
采用大鼠原位鼻腔循环法作为实验模型。研究灌注体积、流速、灌注浓度对栀子苷鼻腔吸收的影响。
栀子苷在大鼠鼻腔灌洗液中稳定。在灌注体积为5 mL、流速为2.5 mL·min⁻¹时，栀子苷的吸收速率呈剂量无关的恒定状态。
栀子苷鼻腔吸收机制为一级动力学的被动扩散，吸收速率常数为4.20×10⁻³ 。
