基于单程灌流法的冰片大鼠鼻腔原位吸收研究
[Study on rat nasal absorption in situ of borneol based on single pass perfusion method].
作者信息
Song Xiao, Du Shouying, Lu Yang, Ma Yong, Chen Xiaolan, Wang Yue, Zhang Huixian
机构信息
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Sep;36(18):2489-92.
OBJECTIVE
To investigate the absorption characteristic of borneol.
METHOD
Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied.
RESULT
Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact.
CONCLUSION
the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.
目的
研究冰片的吸收特性。
方法
采用单通道灌注模型，用气相色谱法检测冰片的有效成分。研究药物浓度、灌注速率和pH值对冰片吸收的影响。
结果
灌注速率对吸收速率常数（Ka）有显著影响。药物浓度和pH值对吸收速率常数无显著影响。
结论
冰片经鼻吸收良好。冰片的吸收速率常数不受药物浓度影响。冰片的吸收是通过简单扩散进行的。
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