Cheng Jacob Y C, Luu Chi D, Yeo Ian Y S, Chee Soon-Phaik
Singapore National Eye Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Clin Exp Ophthalmol. 2009 Jul;37(5):478-84. doi: 10.1111/j.1442-9071.2009.02062.x.
To investigate the outer and inner retinal function in patients with multiple evanescent white dot syndrome (MEWDS).
The retinal function of three subjects with MEWDS was investigated using one or a combination of full-field electroretinography (ERG), multifocal electroretinography (mfERG) or recording of multifocal oscillatory potentials (mfOP).
In case 1, the scotopic, maximal, photopic and flicker ERG responses of the two eyes were similar but the amplitudes of the dark- and light-adapted OPs were markedly reduced in the affected eye. In cases 2 and 3, the ERG responses were grossly reduced in amplitude and as expected the OPs were also diminished. However, using the mfERG a residual area of 'normal' retinal function in the affected eye was identified. The local OP, assessed by the mfOP, within the residual 'normal' retinal area was reduced as compared with the corresponding retinal area of the fellow unaffected eye. Subsequently, the mfERG responses of the 'normal' retinal area were also reduced.
The OPs were reduced throughout the retina in patients with MEWDS, even in the area with a normal mfERG. The electrophysiological findings suggest that functional abnormality in MEWDS may occur initially in the inner retina and subsequently involves the outer retina.
研究多发性一过性白点综合征（MEWDS）患者的视网膜外层和内层功能。
使用全视野视网膜电图（ERG）、多焦视网膜电图（mfERG）或多焦振荡电位（mfOP）记录中的一种或组合，对3例MEWDS患者的视网膜功能进行研究。
病例1中，双眼的暗视、最大反应、明视和闪烁ERG反应相似，但患眼暗适应和光适应OPs的振幅明显降低。病例2和3中，ERG反应的振幅大幅降低，且如预期的那样，OPs也减弱。然而，使用mfERG在患眼中发现了一个“正常”视网膜功能的残留区域。与对侧未受影响眼的相应视网膜区域相比，通过mfOP评估的残留“正常”视网膜区域内的局部OP降低。随后，“正常”视网膜区域的mfERG反应也降低。
MEWDS患者整个视网膜的OPs均降低，即使在mfERG正常的区域也是如此。电生理结果表明，MEWDS的功能异常可能最初发生在内层视网膜，随后累及外层视网膜。
